2015
Biosimilar biologics: never identical but close enough
Abi‐Raad R, Smith BR. Biosimilar biologics: never identical but close enough. Transfusion 2015, 55: 229-231. PMID: 25683185, DOI: 10.1111/trf.12961.Peer-Reviewed Original Research
2007
Circulating stem cells in extremely preterm neonates
Bizzarro MJ, Bhandari V, Krause DS, Smith BR, Gross I. Circulating stem cells in extremely preterm neonates. Acta Paediatrica 2007, 96: 521-525. PMID: 17391470, DOI: 10.1111/j.1651-2227.2007.00194.x.Peer-Reviewed Original ResearchConceptsWeeks of lifePreterm neonatesNeonatal morbidityPulmonary functionPremature neonatesGestational agePeripheral bloodInitial CD34Median gestational agePulmonary function testsShort-term outcomesUmbilical cord bloodFunction testsNeonatal demographicsBirth weightCord bloodRespiratory diseaseNeonatesCell countCD34Progenitor cellsInverse correlationWeeksBloodMorbidity
1998
Peripheral blood progenitor cell cycle kinetics following priming with pIXY321 in patients treated with the "ICE" regimen.
Murren JR, Gollerkeri A, Anderson S, Lutzker S, Del Prete S, Zelterman D, Garrison L, Smith B. Peripheral blood progenitor cell cycle kinetics following priming with pIXY321 in patients treated with the "ICE" regimen. The Yale Journal Of Biology And Medicine 1998, 71: 355-65. PMID: 10527363, PMCID: PMC2578930.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Non-Small-Cell LungCarcinoma, Small CellCell CycleEtoposideFemaleGranulocyte-Macrophage Colony-Stimulating FactorHematopoietic Stem CellsHumansIfosfamideInterleukin-3Lung NeoplasmsMaleMiddle AgedNeutropeniaRecombinant Fusion ProteinsSurvival RateTreatment OutcomeConceptsCell lung cancerPeripheral bloodLung cancerGrowth factorProgenitor cellsDay 1Non-small cell lung cancerSmall cell lung cancerCycle-specific chemotherapyCell cycle distributionHematopoietic growth factorsProgenitor cell cyclingHematologic recoveryPartial responseHematopoietic progenitor cellsCell cycle kineticsPreclinical dataCertain growth factorsSpecific chemotherapySubcutaneous injectionTransient fallCycling progenitor cellsReduced riskPatientsMarrow compartment
1994
B-Cell Precursor Bone Marrow Reconstitution After Bone Marrow Transplantation
Leitenberg D, Rappeport J, Smith B. B-Cell Precursor Bone Marrow Reconstitution After Bone Marrow Transplantation. American Journal Of Clinical Pathology 1994, 102: 231-236. PMID: 8042594, DOI: 10.1093/ajcp/102.2.231.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDB-LymphocytesBlotting, SouthernBone MarrowBone Marrow CellsBone Marrow TransplantationChildChild, PreschoolClone CellsFemaleFlow CytometryFluorescent Antibody TechniqueGene Rearrangement, B-Lymphocyte, Heavy ChainHematopoietic Stem CellsHumansImmunophenotypingInfantKineticsMaleMiddle AgedNeprilysinConceptsBone marrow transplantationMarrow transplantationB cell subsetsBone marrow reconstitutionB cell precursorsSurface antigenic phenotypeImmature B cellsImmunoglobulin gene rearrangementsHumoral immunodeficiencyMonoclonal gammapathyMarrow reconstitutionAntigenic phenotypeB cellsTransplantationGene rearrangementsMarked increaseLeukemia lymphoblastsCellsPatientsGammapathyImmunodeficiencyMarrowCD34ReconstitutionMonths
1990
Retroviral mediated gene transfer into bone marrow progenitor cells: use of beta-galactosidase as a selectable marker
Strair R, Towle M, Smith B. Retroviral mediated gene transfer into bone marrow progenitor cells: use of beta-galactosidase as a selectable marker. Nucleic Acids Research 1990, 18: 4759-4762. PMID: 2118622, PMCID: PMC331937, DOI: 10.1093/nar/18.16.4759.Peer-Reviewed Original Research
1986
FUNCTIONAL ASSESSMENT OF T CELL DEPLETION FROM BONE MARROW PRIOR TO THERAPEUTIC TRANSPLANTATION USING LIMITING DILUTION CULTURE METHODS
Rozans M, Smith B, Emerson S, Crimmins M, Laurent G, Reichert T, Burakoff S, Miller R. FUNCTIONAL ASSESSMENT OF T CELL DEPLETION FROM BONE MARROW PRIOR TO THERAPEUTIC TRANSPLANTATION USING LIMITING DILUTION CULTURE METHODS. Transplantation 1986, 42: 380-386. PMID: 3094209, DOI: 10.1097/00007890-198610000-00010.Peer-Reviewed Original ResearchConceptsT-cell depletionT cellsComplement-mediated depletionCell depletionFACS analysisIL-2Functional impairmentT-lymphocyte depletionT-cell contaminationBone marrow inoculumT cell setsComplement-mediated lysisDilution methodFlow cytometric methodLymphocyte depletionComplement treatmentMarrow inoculumCytotoxic effectorsInterleukin-2Functional assessmentT101 immunotoxinCulture methodCytometric methodCell contaminationEventual deathLong-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods.
Rozans MK, Smith BR, Burakoff SJ, Miller RA. Long-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods. The Journal Of Immunology 1986, 136: 4040-8. PMID: 2939139, DOI: 10.4049/jimmunol.136.11.4040.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone Marrow TransplantationChildChild, PreschoolClone CellsFlow CytometryHematopoietic Stem CellsHumansImmunologic Deficiency SyndromesInfantInfant, NewbornInterleukin-2Leukocyte CountLymphocyte ActivationLymphocyte Culture Test, MixedT-LymphocytesT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerTime FactorsConceptsBone marrow transplantationBMT patientsHuman bone marrow transplant recipientsAllogeneic bone marrow transplantationBone marrow transplant recipientsNormal levelsResidual immune dysfunctionT cell frequenciesMarrow transplant recipientsDilution methodT cell precursorsNear-normal levelsTransplant recipientsBMT recipientsImmune dysfunctionMarrow transplantationPrecursor frequencyLeu-3Immune functionNormal controlsPatientsLeu-2Cell frequencyDecreased frequencyCell precursors