2000
Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodil
Zhang X, Bunney B, Shi W. Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodil. Synapse 2000, 37: 56-63. PMID: 10842351, DOI: 10.1002/(sici)1098-2396(200007)37:1<56::aid-syn6>3.0.co;2-d.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAnimalsDizocilpine MaleateDose-Response Relationship, DrugDrug SynergismElectrophysiologyExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGlycineKynurenic AcidMaleMembrane PotentialsN-MethylaspartateOrgan Culture TechniquesPiperidinesPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSpermineConceptsLow NMDA concentrationsNMDA currentsNMDA concentrationReceptor affinityNMDA receptor affinityEffects of ifenprodilNR2B-selective antagonist ifenprodilEnhancement of NMDARat brain slicesNMDA receptorsAntagonist selectiveBrain slicesSubcortical areasNR2B subunitNMDANoncompetitive antagonistIfenprodilCGP37849Same concentrationKynurenatePrevious studiesAntagonistReceptors
1994
The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat
Goldstein L, Rasmusson A, Bunney B, Roth R. The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. Journal Of Neuroscience 1994, 14: 4937-4950. PMID: 8046462, PMCID: PMC6577203, DOI: 10.1523/jneurosci.14-08-04937.1994.Peer-Reviewed Original ResearchConceptsStress-induced increaseNMDA glycine-site antagonistsDA utilizationGlycine modulatory siteGlycine site antagonistHA-966Conditioned stressPrefrontal cortexCortical dopamineSite antagonistNucleus accumbensControl animalsModulatory siteMedial prefrontal cortical dopamineLateral prefrontal cortexPrefrontal cortical dopamineSerum corticosterone levelsNMDA receptor complexPost-traumatic stress disorderMedial prefrontal cortexNeurotransmitter ratiosRegional dopamineSerotonin utilizationSerum corticosteroneNMDA receptors