2007
Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area
Shi W, Zhang X, Pun C, Bunney B. Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area. Neuropsychopharmacology 2007, 32: 1922-1928. PMID: 17299514, DOI: 10.1038/sj.npp.1301334.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA neuronsVentral tegmental areaD-amphetamineDA receptorsExcitatory effectsTegmental areaΑ1 receptor antagonist prazosinAtypical antipsychotic drug clozapineChloral hydrate-anesthetized ratsTypical antipsychotic drug haloperidolCentral dopamine transmissionCurrent antipsychotic drugsReceptor antagonist prazosinAntipsychotic drug haloperidolAntipsychotic drug clozapineAntagonist prazosinExcitatory pathwaysDA transmissionDopamine neuronsΑ1 receptorsSystemic administrationAntipsychotic drugsExcitatory inputsIncomplete blockade
1977
Electrophysiological studies of dopamine- innervated cells in the frontal cortex.
Bunney B, Aghajanian G. Electrophysiological studies of dopamine- innervated cells in the frontal cortex. Advances In Biochemical Psychopharmacology 1977, 16: 65-70. PMID: 329653.Peer-Reviewed Original Research