2007
Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area
Shi W, Zhang X, Pun C, Bunney B. Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area. Neuropsychopharmacology 2007, 32: 1922-1928. PMID: 17299514, DOI: 10.1038/sj.npp.1301334.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA neuronsVentral tegmental areaD-amphetamineDA receptorsExcitatory effectsTegmental areaΑ1 receptor antagonist prazosinAtypical antipsychotic drug clozapineChloral hydrate-anesthetized ratsTypical antipsychotic drug haloperidolCentral dopamine transmissionCurrent antipsychotic drugsReceptor antagonist prazosinAntipsychotic drug haloperidolAntipsychotic drug clozapineAntagonist prazosinExcitatory pathwaysDA transmissionDopamine neuronsΑ1 receptorsSystemic administrationAntipsychotic drugsExcitatory inputsIncomplete blockade
1994
Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment
Youngren K, Moghaddam B, Bunney B, Roth R. Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neuroscience Letters 1994, 165: 41-44. PMID: 8015734, DOI: 10.1016/0304-3940(94)90704-8.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexChronic treatmentNucleus accumbensPrefrontal cortexChronic clozapine treatmentBasal dopamine releaseExtracellular dopamine levelsChronic clozapineClozapine treatmentIntracerebral microdialysisAcute doseDopaminergic toneDopamine levelsDopamine releaseExtracellular dopamineRat striatumDopamine overflowClozapineBrain regionsPreferential activationStriatumAccumbensCortexTreatmentMicrodialysis
1992
Clozapine: A Hypothesised Mechanism for its Unique Clinical Profile
Bunney B. Clozapine: A Hypothesised Mechanism for its Unique Clinical Profile. The British Journal Of Psychiatry. Supplement 1992, 160: 17-21. PMID: 1418885, DOI: 10.1192/s0007125000296864.Peer-Reviewed Original Research
1990
Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
Moghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexOutflow of dopamineRelease of dopamineNucleus accumbensAntipsychotic drugsPrefrontal cortexAcute effectsExtracellular levelsAtypical antipsychotic drug clozapineVivo microdialysis studyAtypical antipsychotic drugsEffects of sulpirideEffects of haloperidolAntipsychotic drug clozapineMicrodialysis studyVivo microdialysisDrug clozapineHaloperidolStriatumAccumbensCortexSulpirideExtracellular concentrationDopamineDrugsUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1985
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
Chiodo L, Bunney B. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. Journal Of Neuroscience 1985, 5: 2539-2544. PMID: 2863337, PMCID: PMC6565310, DOI: 10.1523/jneurosci.05-09-02539.1985.Peer-Reviewed Original ResearchConceptsDA neuronsClozapine administrationChronic treatmentDepolarization inactivationExtracellular single cell recording techniquesInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidVentral tegmental area (VTA) dopamineSingle cell recording techniquesA10 DA neuronsVivo spontaneous activityMidbrain DA neuronsChloral hydrate anesthesiaCombination of drugsMidbrain dopamine neuronsGamma-aminobutyric acidDifferential effectsMechanism of actionAcute treatmentMicroiontophoretic applicationSubstantia nigraReceptor antagonistDA cellsDopamine neuronsSpontaneous activity
1983
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
Chiodo L, Bunney B. Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal Of Neuroscience 1983, 3: 1607-1619. PMID: 6135762, PMCID: PMC6564520, DOI: 10.1523/jneurosci.03-08-01607.1983.Peer-Reviewed Original ResearchConceptsExtrapyramidal side effectsDepolarization inactivationA10 neuronsAntipsychotic drugsDA neuronsDopaminergic neuronsSide effectsExtracellular single-unit recording techniquesExcitatory amino acid glutamateInhibitory neurotransmitter gamma-aminobutyric acidSingle-unit recording techniquesNeurotransmitter gamma-aminobutyric acidActive DA cellsA10 dopaminergic neuronsMidbrain dopaminergic neuronsGamma-aminobutyric acidActivity of A9Amino acid glutamateChronic administrationMicroiontophoretic applicationNeuroleptic treatmentNeuroleptic administrationAtypical neurolepticsTricyclic antidepressantsDA cells