2000
Anatomic basis of sequence‐dependent predictability exhibited by nigral dopamine neuron firing patterns
Hoffman R, Shi W, Bunney B. Anatomic basis of sequence‐dependent predictability exhibited by nigral dopamine neuron firing patterns. Synapse 2000, 39: 133-138. PMID: 11180500, DOI: 10.1002/1098-2396(200102)39:2<133::aid-syn4>3.0.co;2-k.Peer-Reviewed Original Research
1987
Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences
Chiodo L, Bunney B. Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences. Journal Of Neuroscience 1987, 7: 629-633. PMID: 2881987, PMCID: PMC6569064, DOI: 10.1523/jneurosci.07-03-00629.1987.Peer-Reviewed Original ResearchConceptsDepolarization-induced inactivationFiring rateDopaminergic neuronsDopamine receptor agonist apomorphineMonths' continuous treatmentAcute oral administrationBasal firing rateActive DA neuronsReceptor agonist apomorphineA10 dopaminergic neuronsActive dopamine neuronsClassical antipsychotic drugsDopamine-containing neuronsPresence of haloperidolHr of administrationLong-term treatmentMidbrain dopaminergic neuronsCholecystokinin receptor antagonistAge-matched controlsHaloperidol resultsA10 regionDA neuronsAcute administrationAgonist apomorphineNeuroleptic haloperidolChronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?
Freeman A, Bunney B. Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects? Psychopharmacology Series 1987, 3: 225-235. PMID: 2881290, DOI: 10.1007/978-3-642-71288-3_26.Peer-Reviewed Original ResearchConceptsMost psychotic patientsDA receptor blockerTreatment of choiceDopamine neuron activityCentral catecholamine systemsReceptor blockadeReceptor blockersCatecholamine neuronsNeuroleptic effectsMajor symptomsAntipsychotic drugsCatecholamine systemsAntipsychotic propertiesForebrain regionsNeuronal activityCatecholamine receptorsSide effectsDopamine systemNeuron activityPsychotic patientsTherapeutic efficacyMode of actionFeedback pathwaysTreatmentNeuroleptics
1980
Acute and chronic haloperidol treatment: effects on nigrostriatal dopaminergic system activity.
Bunney B, Skirboll L, Grace A. Acute and chronic haloperidol treatment: effects on nigrostriatal dopaminergic system activity. Advances In Biochemical Psychopharmacology 1980, 24: 267-73. PMID: 7405666.Peer-Reviewed Original Research
1979
The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat
Skirboll L, Bunney B. The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat. Life Sciences 1979, 25: 1419-1433. PMID: 522610, DOI: 10.1016/0024-3205(79)90420-x.Peer-Reviewed Original ResearchConceptsCaudate nucleusIontophoretic dopamineChronic HAL treatmentChronic haloperidol treatmentDifferent treatment regimensEffects of haloperidolDays of treatmentType IDrug terminationPostsynaptic supersensitivityHaloperidol treatmentTardive dyskinesiaTreatment regimensDaily dosesHAL treatmentSingle doseSpontaneous activitySupersensitive responseTreatment groupsType I unitsHaloperidolType II unitsInhibitory effectDopamineActive type I
1978
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney B, Grace A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 1978, 23: 1715-1727. PMID: 31529, DOI: 10.1016/0024-3205(78)90471-x.Peer-Reviewed Original ResearchConceptsChronic haloperidol treatmentDA cellsHaloperidol treatmentControl animalsCell activityExtracellular single-unit recordingsDopaminergic cell activityDopaminergic neuronal activityNigral DA cellsNeurological side effectsDopamine cell activitySingle-unit recordingsFeedback pathwaysComparison of effectsDA neuronsTime-dependent mannerMicroiontophoretic techniquesClinical effectsKainic acidAntipsychotic drugsDepolarization blockCaudate nucleusNeuronal activitySide effectsUnit recordings