2007
Oscillatory firing of dopamine neurons: Differences between cells in the substantia nigra and ventral tegmental area
Zhang D, Yang S, Jin G, Bunney B, Shi W. Oscillatory firing of dopamine neurons: Differences between cells in the substantia nigra and ventral tegmental area. Synapse 2007, 62: 169-175. PMID: 18081182, DOI: 10.1002/syn.20479.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDA neuronsSubstantia nigraDopamine neuronsTegmental areaSlow oscillationsChloral hydrate-anesthetized ratsSN DA neuronsVTA DA neuronsDegree of burstingVariability of firingAfferent inputAdjacent substantia nigraOscillatory firingFiring rateNeuronsNeuronal oscillationsNigraCellsFiringRatsBrainImportant roleFunctional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area
Gao M, Liu C, Yang S, Jin G, Bunney B, Shi W. Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area. Journal Of Neuroscience 2007, 27: 5414-5421. PMID: 17507563, PMCID: PMC6672349, DOI: 10.1523/jneurosci.5347-06.2007.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVTA DA neuronsDA neuronsPrefrontal cortexPFC neuronsDopamine neuronsTegmental areaAction potential-dependent DA releaseSlow oscillationsChloral hydrate-anesthetized ratsIntra-PFC infusionsFunctional couplingPFC terminalsVTA DAGlutamate releaseDA releaseExcitatory influenceRelay neuronsInhibitory influenceCell activityBrain functionNeuronsImportant new insightsCortexMultiple pathwaysClozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area
Shi W, Zhang X, Pun C, Bunney B. Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area. Neuropsychopharmacology 2007, 32: 1922-1928. PMID: 17299514, DOI: 10.1038/sj.npp.1301334.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA neuronsVentral tegmental areaD-amphetamineDA receptorsExcitatory effectsTegmental areaΑ1 receptor antagonist prazosinAtypical antipsychotic drug clozapineChloral hydrate-anesthetized ratsTypical antipsychotic drug haloperidolCentral dopamine transmissionCurrent antipsychotic drugsReceptor antagonist prazosinAntipsychotic drug haloperidolAntipsychotic drug clozapineAntagonist prazosinExcitatory pathwaysDA transmissionDopamine neuronsΑ1 receptorsSystemic administrationAntipsychotic drugsExcitatory inputsIncomplete blockade
1996
Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons
Shim S, Bunney B, Shi W. Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons. Neuropsychopharmacology 1996, 15: 437-441. PMID: 8914116, DOI: 10.1016/s0893-133x(96)00052-8.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDA neuronsPrefrontal cortexSubstantia nigraPFC lesionsBursting activityFiring rateActive DA cellsSN DA neuronsActive DA neuronsMidbrain dopamine neuronsSingle-unit recordingsMedial prefrontal cortexDA cellsDopamine neuronsTegmental areaLocal injectionIbotenic acidUnit recordingsLesionsSame lesionNeuronsRatsActivityCortexChronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.
Sklair-Tavron L, Shi W, Lane S, Harris H, Bunney B, Nestler E. Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11202-11207. PMID: 8855333, PMCID: PMC38308, DOI: 10.1073/pnas.93.20.11202.Peer-Reviewed Original ResearchConceptsVTA dopamine neuronsVentral tegmental areaChronic morphine treatmentDopamine neuronsMorphine treatmentBrain regionsBrain-derived neurotrophic factorIntra-VTA infusionMorphine-treated ratsOpioid receptor antagonistChronic opiate exposureMesolimbic dopamine neuronsFluorescent dye Lucifer yellowMesolimbic dopamine functionMesolimbic dopamine systemImportant neural substrateDye Lucifer yellowNondopaminergic neuronsVTA neuronsChronic morphineOpiate exposureConcomitant treatmentDopaminergic neuronsNeurotrophic factorReceptor antagonist
1992
Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons
Shi W, Bunney B. Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons. Journal Of Neuroscience 1992, 12: 2433-2438. PMID: 1318960, PMCID: PMC6575923, DOI: 10.1523/jneurosci.12-06-02433.1992.Peer-Reviewed Original ResearchConceptsDopamine-induced inhibitionEffects of neurotensinDopamine neuronsIntracellular cAMPAdenylate cyclaseAction of neurotensinRat midbrain slicesAction of dopamineVentral tegmental areaMidbrain dopamine neuronsIntracellular cAMP levelsMidbrain slicesSubstantia nigraTegmental areaDopamine cellsDopamine effectsSpontaneous activityModulatory effectsNeurotensinIsobutyl methylxanthineInhibitory effectNeuronsCAMP levelsProtein kinase CInhibition
1989
The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons
Esposito E, Bunney B. The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons. European Journal Of Pharmacology 1989, 162: 109-113. PMID: 2656273, DOI: 10.1016/0014-2999(89)90609-2.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaVentral tegmental areaActive DA neuronsSCH 23390Chronic treatmentDA neuronsDopamine neuronsDepolarization blockSpontaneous activityDA receptor blockadeAcute subcutaneous injectionGroups of ratsMidbrain dopamine neuronsChronic haloperidolReceptor blockadeChronic administrationPars compactaTegmental areaAntipsychotic drugsSubcutaneous injectionChronic experimentsMarked reductionNeuronsTreatmentHaloperidol
1981
Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons
Skirboll L, Grace A, Hommer D, Rehfeld J, Goldstein M, Hökfelt T, Bunney B. Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons. Neuroscience 1981, 6: 2111-2124. PMID: 6120481, DOI: 10.1016/0306-4522(81)90002-6.Peer-Reviewed Original ResearchConceptsCholecystokinin-like peptidesVentral tegmental areaDopaminergic neuronsFiring rateSubstantia nigraTegmental areaDopaminergic cellsExtracellular single-unit recording techniquesMidbrain dopamine-containing neuronsSingle-unit recording techniquesDopamine-containing neuronsBrain dopaminergic systemDopamine-rich areasMidbrain dopamine neuronsDepolarization inactivationResponsive neuronsDopamine neuronsDopaminergic systemComparable dosesTyrosine hydroxylaseCholecystokininBursting activityNeuronsImmunocytochemical techniquesRecording techniques
1973
Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones
BUNNEY B, AGHAJANIAN G, ROTH R. Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones. Nature 1973, 245: 123-125. PMID: 4518113, DOI: 10.1038/newbio245123a0.Peer-Reviewed Original ResearchConceptsDopamine receptorsAdjacent ventral tegmental areaL-DOPASubstantia nigra zona compactaFiring rateVentral tegmental areaAvailability of dopamineAromatic amino acid decarboxylaseDopamine-containing cellsAmount of dopamineComparison of effectsZona compactaTegmental areaD-amphetamineDopaminergic neuronesAmino acid decarboxylaseReceptor stimulationAcid decarboxylaseDopamineReceptorsApomorphineDrugsStimulationFeedback inhibitionCompacta