2007
Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area
Gao M, Liu C, Yang S, Jin G, Bunney B, Shi W. Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area. Journal Of Neuroscience 2007, 27: 5414-5421. PMID: 17507563, PMCID: PMC6672349, DOI: 10.1523/jneurosci.5347-06.2007.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVTA DA neuronsDA neuronsPrefrontal cortexPFC neuronsDopamine neuronsTegmental areaAction potential-dependent DA releaseSlow oscillationsChloral hydrate-anesthetized ratsIntra-PFC infusionsFunctional couplingPFC terminalsVTA DAGlutamate releaseDA releaseExcitatory influenceRelay neuronsInhibitory influenceCell activityBrain functionNeuronsImportant new insightsCortexMultiple pathways
1992
Actions of Neurotensin: A Review of the Electrophysiological Studiesa
SHI W, BUNNEY B. Actions of Neurotensin: A Review of the Electrophysiological Studiesa. Annals Of The New York Academy Of Sciences 1992, 668: 129-145. PMID: 1463269, DOI: 10.1111/j.1749-6632.1992.tb27345.x.Peer-Reviewed Original ResearchMeSH KeywordsNeurotensinConceptsExcitatory effectsDA cellsModulatory effectsDA receptor blockadeDirect postsynaptic effectAction of neurotensinGlutamate-induced excitationMidbrain DA cellsMembrane conductancePostsynaptic effectsReceptor blockadeDepolarization inactivationNT receptorsCell activityFiring rateSame receptorNeuromedin NSudden cessationHigh concentrationsProtein kinase CBasal activityToxic effectsInhibitionNeurotensinReceptors
1991
Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex?
Shi W, Bunney B. Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex? Synapse 1991, 9: 157-164. PMID: 1776128, DOI: 10.1002/syn.890090302.Peer-Reviewed Original ResearchConceptsEffects of neurotensinNeurotensin receptorsDopamine neuronsDopamine cellsCell activitySingle-unit recording techniquesFiring rateMidbrain dopamine neuron activityAction of neurotensinBasal firing rateDopamine receptor blockadeDopamine-induced inhibitionDopamine neuron activityMidbrain dopamine neuronsReceptor blockadeDepolarization inactivationExcitatory effectsNative neurotensinBrain slicesNeuron activityNeurotensinNeurotensin analoguesSame receptorRecording techniquesReceptorsNeurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity
Shi W, Bunney B. Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity. Brain Research 1991, 543: 315-321. PMID: 1676331, DOI: 10.1016/0006-8993(91)90043-u.Peer-Reviewed Original ResearchConceptsDA cellsCell activityFiring rateDA cell activityInteraction of neurotensinGlutamate-induced excitationEffects of neurotensinMidbrain dopamine cell activityDopamine cell activityMidbrain dopamine neuronsSpecific D2 agonistMicroiontophoretic techniquesD2 agonistDopamine neuronsD2 receptorsDopamine effectsSpontaneous activityNeurotensinNT effectsLocal ejectionInhibitionSignificant changesCellsCell levelSame cells
1988
Effects of Acute and Chronic Neuroleptic Treatment on the Activity of Mid brain Dopamine Neuronsa
BUNNEY B. Effects of Acute and Chronic Neuroleptic Treatment on the Activity of Mid brain Dopamine Neuronsa. Annals Of The New York Academy Of Sciences 1988, 537: 77-85. PMID: 2904786, DOI: 10.1111/j.1749-6632.1988.tb42097.x.Peer-Reviewed Original ResearchConceptsAD administrationDA releaseDA cell activityChronic neuroleptic treatmentMidbrain DA neuronsRelease of DAEffects of AcuteNeurological side effectsDA neuronsNeuroleptic treatmentAcute effectsNerve terminalsSpontaneous activitySide effectsCell activityMarked increaseAdministrationProjection areaPrimary effectReleaseAcuteMarked effectNeuronsActivityBiochemical techniques
1987
Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin
Freeman A, Bunney B. Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin. Brain Research 1987, 405: 46-55. PMID: 3032350, DOI: 10.1016/0006-8993(87)90988-7.Peer-Reviewed Original ResearchConceptsCCK-8A9 neuronsDA neuronsDopaminergic neuronsUnrestrained ratsVentral tegmental area cellsFiring rateCCK-8 pretreatmentDA cell activitySingle dopaminergic neuronsEffects of apomorphineA10 dopaminergic neuronsActivity of A9Sulfated CCK-8A10 neuronsDA agonistsAnesthetized ratsParalyzed ratsSequential dosesA10 cellsCell activityCell firingUnit firingUnit activityApomorphine
1985
An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system
Clark D, Engberg G, Pileblad E, Svensson T, Carlsson A, Freeman A, Bunney B. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system. Naunyn-Schmiedeberg's Archives Of Pharmacology 1985, 329: 344-354. PMID: 4033804, DOI: 10.1007/bf00496366.Peer-Reviewed Original ResearchConceptsPostsynaptic DA receptorsInhibitory actionDA autoreceptorsDA receptorsNeuronal activityDA cell firing rateExtracellular single-unit recordingsCaudate neuronal activityDA neuronal activityGallamine-paralyzed ratsNigrostriatal DA systemNigrostriatal dopamine systemSingle-unit recordingsCell firing rateReticulata neuronsDA agonistsDA cellsIntravenous administrationMajority of cellsDopamine systemN-propylpiperidineUnit recordingsPartial agonistCell activityFiring rate
1984
Antipsychotic drug effects on the electrical activity of dopaminergic neurons
Bunney B. Antipsychotic drug effects on the electrical activity of dopaminergic neurons. Trends In Neurosciences 1984, 7: 212-215. DOI: 10.1016/s0166-2236(84)80013-2.Peer-Reviewed Original ResearchClinical effectsAntipsychotic drugsChronic studiesAntipsychotic drug effectsDopamine cell activityCell firing rateMechanism of actionDopaminergic neuronsDrug effectsCell activityElectrophysiological techniquesFiring rateBehavioral effectsDrugsElectrical activityTime-dependent changesNeuronsCellular sitesChemical messengersSpecific actionsActivity
1980
Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment
Grace A, Bunney B. Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment. Brain Research Bulletin 1980, 5: 537-543. DOI: 10.1016/0361-9230(80)90087-8.Peer-Reviewed Original ResearchChronic haloperidol treatmentDopaminergic cell activityEffects of baclofenHaloperidol treatmentLow dosesExtracellular single-unit recording techniquesNeuroleptic-induced side effectsRat nigral dopaminergic neuronsCell activitySingle-unit recording techniquesInhibitory effectNigral DA cellsSingle low dosesNigral dopaminergic neuronsTreatment of spasticityAction of baclofenDose-response curveMechanism of actionDepolarization inactivationDopaminergic neuronsHaloperidol pretreatmentDA cellsPossible efficacyNigral inputsBaclofen
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonistsEFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY
Bunney B, Grace A. EFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY. 1979, 666-668. DOI: 10.1016/b978-1-4832-8363-0.50202-0.Peer-Reviewed Original ResearchActive DA cellsChronic haloperidol treatmentDA cellsExtracellular single-unit recording techniquesRat nigral dopaminergic neuronsSingle-unit recording techniquesNigral dopaminergic neuronsNeurological side effectsEffects of chronicDepolarization inactivationHaloperidol treatmentDopaminergic neuronsExcitatory inputsSide effectsCell activityRecording techniquesPossible new mechanismSubsequent studiesTreatmentCellsAnimalsNigralChronicNeurons
1978
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney B, Grace A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 1978, 23: 1715-1727. PMID: 31529, DOI: 10.1016/0024-3205(78)90471-x.Peer-Reviewed Original ResearchConceptsChronic haloperidol treatmentDA cellsHaloperidol treatmentControl animalsCell activityExtracellular single-unit recordingsDopaminergic cell activityDopaminergic neuronal activityNigral DA cellsNeurological side effectsDopamine cell activitySingle-unit recordingsFeedback pathwaysComparison of effectsDA neuronsTime-dependent mannerMicroiontophoretic techniquesClinical effectsKainic acidAntipsychotic drugsDepolarization blockCaudate nucleusNeuronal activitySide effectsUnit recordings
1976
Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques
Bunney B, Aghajanian G. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques. Life Sciences 1976, 19: 1783-1792. PMID: 1004134, DOI: 10.1016/0024-3205(76)90087-4.Peer-Reviewed Original ResearchConceptsRat prefrontal cortexMicroiontophoretic techniquesLayer VLayers IIPrefrontal cortexUptake blockersInhibitory effectNE uptake blockerDA receptor blockerCortical layers IIDA uptake blockersReceptor blockersDA inhibitionNoradrenergic projectionsAccumbens nucleusPharmacological differentiationNorepinephrineCell activitySensitivity of cellsHistochemical evidenceBlockersCortexDopamineSensitive cellsSuperficial layersd-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway
Bunney B, Achajanian G. d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway. Science 1976, 192: 391-393. PMID: 1257777, DOI: 10.1126/science.1257777.Peer-Reviewed Original ResearchConceptsD-amphetamineDepressant effectDopaminergic cell activityIntravenous d-amphetamineCentral dopaminergic neuronsStriato-nigral pathwayNeuronal feedback loopMicroiontophoretic applicationDopaminergic neuronsDopaminergic cellsCell activitySignificant slowingFeedback pathwaysPrevious dataCellsLesionsPathwayNeurons