2024
Manifestations of human atherosclerosis across vascular beds
Jovin D, Sumpio B, Greif D. Manifestations of human atherosclerosis across vascular beds. JVS-Vascular Insights 2024, 2: 100089. DOI: 10.1016/j.jvsvi.2024.100089.Peer-Reviewed Original ResearchVascular bedClinical managementCarotid arteryCommon risk factorsPeripheral arterial diseaseManagement of carotidClinical management of atherosclerosisEtiology of mortalityIntervention outcomesModel of atherogenesisPathology of atherosclerotic lesionsMedical therapyMeta-analysesTreatment responseFibrotic componentManagement of atherosclerosisLower extremitiesMale sexClinical studiesArtery diseaseMetabolic factorsPeripheral atherosclerosisRisk factorsIndividual patientsVascular territories
2016
Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
Sumpio BJ, Citoni G, Chin JA, Sumpio BE. Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease. Journal Of Vascular Surgery 2016, 64: 1066-1073. PMID: 27266597, DOI: 10.1016/j.jvs.2016.03.463.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBrachial ArteryCase-Control StudiesCoronary Artery DiseaseCross-Sectional StudiesEndothelium, VascularFemaleHemoglobinsHumansHyperemiaMaleMicrocirculationMiddle AgedMolecular ImagingOxyhemoglobinsPeripheral Arterial DiseasePilot ProjectsPredictive Value of TestsProspective StudiesReproducibility of ResultsSeverity of Illness IndexSkinSpectrum AnalysisUpper ExtremityVasodilationConceptsPeripheral artery diseaseCoronary artery diseaseCuff occlusionUpper armArtery diseaseVascular dysfunctionArterial diseasePresence of PADArterial disease patientsPeripheral arterial diseaseSystemic vascular dysfunctionAdvanced diseaseEndothelial dysfunctionVascular clinicProspective studySurgical historyControl cohortDisease patientsMedical recordsUpper extremityVascular bedHealthy volunteersPatientsHemoglobin concentrationDemographic data
1995
Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: Species and vascular bed diversity
Du W, Mills I, Sumpio B. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: Species and vascular bed diversity. Journal Of Biomechanics 1995, 28: 1485-1491. PMID: 8666588, DOI: 10.1016/0021-9290(95)00096-8.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 2AnimalsAortaCattleCell DivisionCyclic AMP Response Element-Binding ProteinEndothelium, VascularEpoprostenolGene Expression RegulationGenes, Immediate-EarlyHumansNF-kappa BNuclear ProteinsPhenotypeProtein Kinase CSpecies SpecificityStress, MechanicalTime FactorsTranscription Factor AP-1Transcription FactorsUmbilical VeinsConceptsHuman umbilical vein endothelial cellsBovine aortic endothelial cellsActivator protein-1NF-kBEndothelial cellsVascular bedDifferent vascular bedsUmbilical vein endothelial cellsAortic endothelial cellsCultured endothelial cellsTranscription factor activator protein-1Vein endothelial cellsProstacyclin secretionStretch-induced activationImmediate early genesEC exposureNuclear factorTime pointsHeterogeneous inductionCAMP response elementProtein 1Biphasic mannerSignificant inductionDivergent effectsHuman aorta