2023
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCerebral CortexCerebrovascular CirculationHypercapniaMiceNeurovascular CouplingOlfactory BulbConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic waste
2020
Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI
Sanganahalli BG, Baker KL, Thompson GJ, Herman P, Shepherd GM, Verhagen JV, Hyder F. Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI. NeuroImage 2020, 212: 116664. PMID: 32087375, PMCID: PMC9362851, DOI: 10.1016/j.neuroimage.2020.116664.Peer-Reviewed Original ResearchConceptsRat olfactory bulbOlfactory bulbWhole olfactory bulbOlfactory receptor neuronsFunctional MRINasal cavityRetronasal stimuliGlomerular sheetDorsal-medial regionsDelivery routeRetronasal stimulationSimilar response amplitudesGlomerular activityFMRI activation mapsSame odorReceptor neuronsDorsal regionNeural responsesOdor representationsLateral regionsSame odorantOrthonasalUnderlie differencesResponse amplitudeResponse patterns
2018
Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb
Thompson GJ, Sanganahalli BG, Baker KL, Herman P, Shepherd GM, Verhagen JV, Hyder F. Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb. NeuroImage 2018, 172: 586-596. PMID: 29374582, PMCID: PMC5910178, DOI: 10.1016/j.neuroimage.2018.01.051.Peer-Reviewed Original Research
2015
Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping
Sanganahalli BG, Rebello MR, Herman P, Papademetris X, Shepherd GM, Verhagen JV, Hyder F. Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping. NeuroImage 2015, 126: 208-218. PMID: 26631819, PMCID: PMC4733588, DOI: 10.1016/j.neuroimage.2015.11.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingCalciumMagnetic Resonance ImagingOdorantsOlfactory BulbOptical ImagingRatsRats, Sprague-DawleySmellConceptsFunctional magnetic resonance imagingHigh-resolution functional magnetic resonance imagingPost-synaptic activityPre-synaptic inputOlfactory bulb glomeruliFunctional imaging signalsWide-field calcium imagingMagnetic resonance imagingHemodynamic eventsAnesthetized ratsGlomerular layerNeuronal circuitryGlomerular clustersGlomerular patternNeuropil regionsCalcium imagingDye imagingResonance imagingActivity patternsDeoxyhemoglobin contrastGlomerular activity patternsGlomerular sheetGlomerular networkGlomeruli