2022
Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
Fowler JWM, Zhang R, Tao B, Boutagy NE, Sessa WC. Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells. ELife 2022, 11: e79529. PMID: 35959888, PMCID: PMC9395194, DOI: 10.7554/elife.79529.Peer-Reviewed Original ResearchConceptsAcute inflammatory responseEndothelial cellsCholesterol homeostasisInflammatory stressInflammatory responsePro-inflammatory cytokinesSite of injuryCholesterol biosynthetic gene expressionNF-κB DNA bindingHuman endothelial cellsMultiple sclerosisInflammatory activationPrimary human endothelial cellsVascular endotheliumNF-κB-inducible genesTissue damageInducible targetAberrant activationRole of cholesterolSREBP2 activationMicrobial infectionsCholesterolKey transcription regulatorHomeostasisLeukocytes
2016
Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in vitro
Jin Y, Liu L, Zhang S, Tao B, Tao R, He X, Qu L, Huang J, Wang X, Fu Z. Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in vitro. Chemosphere 2016, 148: 436-443. PMID: 26841286, DOI: 10.1016/j.chemosphere.2016.01.057.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseInterleukin-6Inflammatory responseCyclooxygenase-2 mRNA levelsLipopolysaccharide-induced inflammatory responsesRelease of TNFαNitric oxide synthaseTumor necrosis factorCell linesRAW264.7 cell lineConcentration-dependent mannerSerum levelsInflammatory cellsInterleukin-1βLiver weightOxide synthaseMacrophage cell lineNecrosis factorInterleukin-1αCR pretreatmentCytokine genesPeritoneal macrophagesSerious infiltrationLipopolysaccharideMRNA levels