2022
Oxidative Stress in Traumatic Brain Injury
Fesharaki-Zadeh A. Oxidative Stress in Traumatic Brain Injury. International Journal Of Molecular Sciences 2022, 23: 13000. PMID: 36361792, PMCID: PMC9657447, DOI: 10.3390/ijms232113000.Peer-Reviewed Original ResearchMeSH KeywordsAntioxidantsBrainBrain Injuries, TraumaticHumansLipid PeroxidationOxidative StressReactive Oxygen SpeciesConceptsTraumatic brain injuryAntioxidant therapyBrain injuryClinical settingPost-traumatic brain injuryOxidative stressReactive oxygen speciesUnderlying pathophysiological mechanismsSecondary injury cascadePromising treatment optionLipid peroxidation productsFree radical generating enzymesReal clinical settingNeurometabolic cascadeFree radical scavengerInjury cascadeChronic inflammationPathophysiological mechanismsSynaptic dysfunctionPost injuryTreatment optionsTBI treatmentSide effectsTBI symptomsInjury
2020
Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder
Fesharaki-Zadeh A, Miyauchi JT, St. Laurent-Arriot K, Tsirka SE, Bergold PJ. Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder. ASN Neuro 2020, 12: 1759091420979567. PMID: 33342261, PMCID: PMC7755938, DOI: 10.1177/1759091420979567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningBrain Injuries, TraumaticComorbidityDisease Models, AnimalInflammationMaleMaze LearningMiceReflex, StartleStress Disorders, Post-TraumaticConceptsTraumatic brain injuryPost-traumatic stress disorderChi groupBrain injuryBarnes mazeCo-morbid traumatic brain injuryMale C57/BL6 miceCognitive deficitsComorbid post-traumatic stress disorderC57/BL6 miceStress disorderClosed-head modelIba-1 levelsChronic variable stress modelActive place avoidancePlace avoidanceGreater cognitive deficitsNeuroinflammatory outcomesBasal anxiety levelsCVS groupSham treatmentBL6 miceBehavioral deficitsMouse modelKey underlying mechanism