2019
Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches
Haberman AM, Gonzalez DG, Wong P, Zhang T, Kerfoot SM. Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches. Immunological Reviews 2019, 288: 10-27. PMID: 30874342, PMCID: PMC10234181, DOI: 10.1111/imr.12731.Peer-Reviewed Original Research
2018
Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions.
Gonzalez DG, Cote CM, Patel JR, Smith CB, Zhang Y, Nickerson KM, Zhang T, Kerfoot SM, Haberman AM. Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions. The Journal Of Immunology 2018, 201: 3569-3579. PMID: 30446568, PMCID: PMC6289626, DOI: 10.4049/jimmunol.1500497.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisB-LymphocytesCell DifferentiationCell Self RenewalCells, CulturedGerminal CenterInterleukin-4InterleukinsLymphocyte ActivationMiceMice, KnockoutParacrine CommunicationProto-Oncogene Proteins c-bcl-6Receptors, Interleukin-21Signal TransductionSTAT6 Transcription FactorT-Lymphocytes, Helper-InducerConceptsIL-21IL-4B cellsIL-21RCytokine IL-21Costimulatory molecule expressionB cell folliclesIL-21 signalingGC B cell developmentNonredundant roleGerminal center B cellsMurine model systemGC B cellsMolecule expressionPhenotypic maturationB cell developmentCell expressionCytokine signalsB cell transitionCombined absenceSubsequent maturationCell migrationCell developmentHistone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis
Hatzi K, Geng H, Doane AS, Meydan C, LaRiviere R, Cardenas M, Duy C, Shen H, Vidal MNC, Baslan T, Mohammad HP, Kruger RG, Shaknovich R, Haberman AM, Inghirami G, Lowe SW, Melnick AM. Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis. Nature Immunology 2018, 20: 86-96. PMID: 30538335, PMCID: PMC6294324, DOI: 10.1038/s41590-018-0273-1.Peer-Reviewed Original Research
2017
Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help
Zhang TT, Gonzalez DG, Cote CM, Kerfoot SM, Deng S, Cheng Y, Magari M, Haberman AM. Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help. ELife 2017, 6: e19552. PMID: 28498098, PMCID: PMC5429091, DOI: 10.7554/elife.19552.Peer-Reviewed Original Research
2014
The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers
Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A. The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers. Cell Reports 2014, 8: 1497-1508. PMID: 25176650, PMCID: PMC4163070, DOI: 10.1016/j.celrep.2014.07.059.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell MovementCytokinesDNA-Binding ProteinsGerminal CenterHistone Deacetylase 2Lymphocyte ActivationMiceMutationProtein BindingProtein Structure, TertiaryProto-Oncogene Proteins c-bcl-6Receptors, G-Protein-CoupledReceptors, LysosphingolipidSphingosine-1-Phosphate ReceptorsT-Lymphocytes, Helper-InducerConceptsInnate immune cell phenotypesGC Tfh cellsImmune cell phenotypesT helper cellsGerminal center formationB cells migrateActivated B cellsB cell migrationHelper cellsInflammatory diseasesInterfollicular zonesTranscriptional repressor functionExtrafollicular responseGerminal centersB cellsImmune systemReceptor S1PR1MiceRepression domainRD2 domainRepressor functionCell migrationCells migrateCenter formationBiochemical specificity
2012
In vivo imaging of virological synapses
Sewald X, Gonzalez DG, Haberman AM, Mothes W. In vivo imaging of virological synapses. Nature Communications 2012, 3: 1320. PMID: 23271654, PMCID: PMC3784984, DOI: 10.1038/ncomms2338.Peer-Reviewed Original ResearchConceptsVirological synapsesHuman T-cell lymphotropic virusMurine leukemia virusHuman immunodeficiency virusLeukemia virusViral envelope glycoproteinsLymph nodesImmunodeficiency virusFriend murine leukemia virusLymphotropic virusB cellsIntravital microscopyCell-cell contactEnvelope glycoproteinSynapsesUninfected cellsIntravital imagingVirusMiceVivoCellsLeucocytes
2011
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner
King IL, Fortier A, Tighe M, Dibble J, Watts GF, Veerapen N, Haberman AM, Besra GS, Mohrs M, Brenner MB, Leadbetter EA. Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nature Immunology 2011, 13: 44-50. PMID: 22120118, PMCID: PMC3833037, DOI: 10.1038/ni.2172.Peer-Reviewed Original ResearchGerminal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone
Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, Kleinstein SH, Haberman AM. Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone. Immunity 2011, 34: 947-960. PMID: 21636295, PMCID: PMC3280079, DOI: 10.1016/j.immuni.2011.03.024.Peer-Reviewed Original ResearchActivated germinal centre B cells undergo directed migration.
O'Connor MJ, Hauser AE, Haberman AM, Kleinstein SH. Activated germinal centre B cells undergo directed migration. International Journal Of Data Mining And Bioinformatics 2011, 5: 321-31. PMID: 21805826, PMCID: PMC4343311, DOI: 10.1504/ijdmb.2011.040387.Peer-Reviewed Original Research
2010
Cellular choreography in the germinal center: new visions from in vivo imaging
Hauser AE, Kerfoot SM, Haberman AM. Cellular choreography in the germinal center: new visions from in vivo imaging. Seminars In Immunopathology 2010, 32: 239-255. PMID: 20614218, PMCID: PMC3659422, DOI: 10.1007/s00281-010-0214-z.Peer-Reviewed Original Research
2009
Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells
Anderson SM, Khalil A, Uduman M, Hershberg U, Louzoun Y, Haberman AM, Kleinstein SH, Shlomchik MJ. Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells. The Journal Of Immunology 2009, 183: 7314-7325. PMID: 19917681, PMCID: PMC4106706, DOI: 10.4049/jimmunol.0902452.Peer-Reviewed Original ResearchConceptsLow-affinity B cellsLow-affinity cellsGerminal centersB cellsHigh-affinity B cellsHigh-affinity cellsDeath rateHigh death rateLower death ratesImmune responseHigh-affinity AbsB lymphocytesMemory responsesExtracellular pathogensSame AgPrimary responseGC reactionProliferative advantageSimilar ratesSurvivalCellsCell cycleControl of survivalHigh affinityResponse
2007
New markers for murine memory B cells that define mutated and unmutated subsets
Anderson SM, Tomayko MM, Ahuja A, Haberman AM, Shlomchik MJ. New markers for murine memory B cells that define mutated and unmutated subsets. Journal Of Experimental Medicine 2007, 204: 2103-2114. PMID: 17698588, PMCID: PMC2118690, DOI: 10.1084/jem.20062571.Peer-Reviewed Original ResearchConceptsMemory B cellsMurine memory B cellsB cellsAntigen-specific memory B cellsMemory B cell subsetsMemory B cell markersNon-Tg miceExpression of CD80B-cell markersB cell subsetsTransgenic mouse modelCell subsetsSplenic folliclesMemory compartmentMouse modelNaive precursorsMutation statusCell markersUnmutated subsetDefinitive markerMemory cellsAnatomic heterogeneityNew markersCell numberIn vivo imaging studies shed light on germinal-centre development
Hauser AE, Shlomchik MJ, Haberman AM. In vivo imaging studies shed light on germinal-centre development. Nature Reviews Immunology 2007, 7: 499-504. PMID: 17589541, DOI: 10.1038/nri2120.Peer-Reviewed Original ResearchDefinition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns
Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. Definition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns. Immunity 2007, 26: 655-667. PMID: 17509908, DOI: 10.1016/j.immuni.2007.04.008.Peer-Reviewed Original Research
2003
Reassessing the function of immune-complex retention by follicular dendritic cells
Haberman AM, Shlomchik MJ. Reassessing the function of immune-complex retention by follicular dendritic cells. Nature Reviews Immunology 2003, 3: 757-764. PMID: 12949499, DOI: 10.1038/nri1178.Peer-Reviewed Original ResearchConceptsFollicular dendritic cellsDendritic cellsImmune complexesSurface of FDCsMemory B-cell maintenanceMemory B cell developmentB cell maintenanceGerminal center B cellsGerminal center developmentB cell proliferationAffinity maturationB cell recognitionB cellsB cell developmentPotential roleNon-specific mannerCellsClose associationMaturation
2002
Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced
Dal Porto JM, Haberman AM, Kelsoe G, Shlomchik MJ. Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced. Journal Of Experimental Medicine 2002, 195: 1215-1221. PMID: 11994427, PMCID: PMC2193705, DOI: 10.1084/jem.20011550.Peer-Reviewed Original ResearchConceptsAntibody-forming cellsMemory B cellsImmune responseB cellsB cell antigen receptorT cell-dependent immune responsesCell-dependent immune responsesLow-affinity B cellsH chain transgenic miceMemory B cell populationsHigh affinity competitionSecondary immune responseSpecific immune responseAntigen-specific cellsGerminal center responseSuch B cellsB cell populationsH chain transgeneLate primary responseGerminal centersTransgenic miceCenter responseCell antigen receptorAntigen receptorPrimary response
2000
Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells
Hannum L, Haberman A, Anderson S, Shlomchik M. Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells. Journal Of Experimental Medicine 2000, 192: 931-942. PMID: 11015435, PMCID: PMC2193308, DOI: 10.1084/jem.192.7.931.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodiesAntigen-Antibody ComplexB-LymphocytesDendritic Cells, FollicularFemaleGenes, ImmunoglobulinGerminal CenterHaptensImmunoglobulin lambda-ChainsImmunoglobulin Variable RegionMaleMiceMice, Inbred BALB CMice, TransgenicMolecular Sequence DataNitrophenolsPhenylacetatesReceptors, Antigen, B-CellA B-cell receptor-specific selection step governs immature to mature B cell differentiation
Levine M, Haberman A, Sant'Angelo D, Hannum L, Cancro M, Janeway C, Shlomchik M. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 2743-2748. PMID: 10688906, PMCID: PMC16000, DOI: 10.1073/pnas.050552997.Peer-Reviewed Original ResearchConceptsImmature B cellsMature B cellsB cell receptor repertoirePositive selection eventsB cell differentiationReceptor repertoireSelection eventsCell differentiationB cellsChain pairsCell receptor repertoirePeripheral B cellsReceptor specificityTime cellsMajor forceCell fractionCellsAdaptive immune responsesRepertoireConventional B cellsAvailable repertoireSelection stepImmune responseB cell fractionsSignificant skewing
1999
A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus
Chan O, Hannum L, Haberman A, Madaio M, Shlomchik M. A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus. Journal Of Experimental Medicine 1999, 189: 1639-1648. PMID: 10330443, PMCID: PMC2193634, DOI: 10.1084/jem.189.10.1639.Peer-Reviewed Original ResearchConceptsB cellsAutoantibody productionMRL/MpJ-Faslpr miceAutoreactive T cellsAntigen-presenting cellsAntibody-independent roleB cell functionFunctional B cellsExpression of diseaseSerum autoantibodiesMurine lupusLocal inflammationSystemic autoimmunitySerum antibodiesPathogenic roleAntigen presentationT cellsCellular infiltrationSurface immunoglobulinPathologic phenotypeDisease expressionCell functionMiceNovel mousePrecise role