2024
The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease
Manuello J, Min J, McCarthy P, Alfaro-Almagro F, Lee S, Smith S, Elliott L, Winkler A, Douaud G. The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease. Nature Communications 2024, 15: 2576. PMID: 38538590, PMCID: PMC10973379, DOI: 10.1038/s41467-024-46344-2.Peer-Reviewed Original ResearchConceptsModifiable risk factorsRisk factorsBrain networksUK Biobank participantsTraffic-related air pollutionAlcohol intake frequencyBrain regionsGenome-wide associationBiobank participantsHigher-order brain regionsIntake frequencyXg blood groupEffects of ageCardiovascular deathGenetic influencesUnique contributionsNitrogen dioxideSchizophreniaBrainAgeAir pollutionAlzheimer's diseaseParkinson's diseaseSexAssociation
2023
A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward
Zugman A, Jett L, Antonacci C, Winkler A, Pine D. A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward. Journal Of Anxiety Disorders 2023, 99: 102773. PMID: 37741177, PMCID: PMC10753861, DOI: 10.1016/j.janxdis.2023.102773.Peer-Reviewed Original ResearchConceptsAnxiety disordersSystematic reviewPrevalent psychiatric disordersStrict inclusion criteriaAnterior cingulate cortexMedial frontal gyrusActivation likelihood estimation (ALE) analysisResting-state fMRITime of scanningFunctional imaging modalitiesPatient groupHealthy groupInclusion criteriaHealthy volunteersPsychiatric disordersCingulate cortexStudy numbersRs-fMRIFrontal gyrusDisordersImaging modalitiesPatientsBrain activityFamily-wise errorGyrusMapping Lesion-Related Epilepsy to a Human Brain Network
Schaper F, Nordberg J, Cohen A, Lin C, Hsu J, Horn A, Ferguson M, Siddiqi S, Drew W, Soussand L, Winkler A, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon A, Ackermans L, Bubrick E, Peters J, Wu O, Rost N, Grafman J, Blumenfeld H, Temel Y, Rouhl R, Joutsa J, Fox M. Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology 2023, 80: 891-902. PMID: 37399040, PMCID: PMC10318550, DOI: 10.1001/jamaneurol.2023.1988.Peer-Reviewed Original ResearchConceptsRisk of epilepsyLesion locationBrain regionsPoststroke epilepsyControl patientsSeizure controlBrain lesionsIndependent cohortBrain networksLesion typeBrain stimulation sitesLesion network mappingLesion-related epilepsyImproved seizure controlDrug-resistant epilepsyCase-control studyBrain stimulation therapyHuman brain networksSpecific brain regionsDifferent lesion typesSpecific brain networksBasal gangliaVascular territoriesStimulation therapyMAIN OUTCOMECountry-level gender inequality is associated with structural differences in the brains of women and men
Zugman A, Alliende L, Medel V, Bethlehem R, Seidlitz J, Ringlein G, Arango C, Arnatkevičiūtė A, Asmal L, Bellgrove M, Benegal V, Bernardo M, Billeke P, Bosch-Bayard J, Bressan R, Busatto G, Castro M, Chaim-Avancini T, Compte A, Costanzi M, Czepielewski L, Dazzan P, de la Fuente-Sandoval C, Di Forti M, Díaz-Caneja C, Díaz-Zuluaga A, Du Plessis S, Duran F, Fittipaldi S, Fornito A, Freimer N, Gadelha A, Gama C, Garani R, Garcia-Rizo C, Campo C, Gonzalez-Valderrama A, Guinjoan S, Holla B, Ibañez A, Ivanovic D, Jackowski A, Leon-Ortiz P, Lochner C, López-Jaramillo C, Luckhoff H, Massuda R, McGuire P, Miyata J, Mizrahi R, Murray R, Ozerdem A, Pan P, Parellada M, Phahladira L, Ramirez-Mahaluf J, Reckziegel R, Marques T, Reyes-Madrigal F, Roos A, Rosa P, Salum G, Scheffler F, Schumann G, Serpa M, Stein D, Tepper A, Tiego J, Ueno T, Undurraga J, Undurraga E, Valdes-Sosa P, Valli I, Villarreal M, Winton-Brown T, Yalin N, Zamorano F, Zanetti M, cVEDA, Winkler A, Pine D, Evans-Lacko S, Crossley N, Murthy P, Chakrabarti A, Basu D, Subodh B, Singh L, Singh R, Kalyanram K, Kartik K, Kumaran K, Krishnaveni G, Kuriyan R, Kurpad S, Barker G, Bharath R, Desrivieres S, Purushottam M, Orfanos D, Sharma E, Hickman M, Heron J, Toledano M, Vaidya N. Country-level gender inequality is associated with structural differences in the brains of women and men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2218782120. PMID: 37155867, PMCID: PMC10193926, DOI: 10.1073/pnas.2218782120.Peer-Reviewed Original ResearchConceptsWorse outcomesCaudal anterior cingulateRight caudal anterior cingulateRight medial orbitofrontalAdult healthy menBrains of womenMental health problemsLateral occipital cortexHealthy menRegional cortexHigh riskOccipital cortexCortical thicknessCountry-level gender inequalityMedial orbitofrontalMRI scansThinner cortexAnterior cingulateHealth problemsBrain structuresWomen's brainsWomenBrainCortexRight hemisphereCognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses
Leerssen J, Aghajani M, Bresser T, Rösler L, Winkler A, Foster-Dingley J, Van Someren E. Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 60-69. PMID: 36958474, DOI: 10.1016/j.bpsc.2023.03.007.Peer-Reviewed Original ResearchConceptsAmygdala responseSleep interventionsEmotion-related brain activityFunctional magnetic resonance imaging studyEmotional brain responsesInsomnia treatmentFunctional magnetic resonance imagingCognitive behavioral therapyMagnetic resonance imaging studyEmotional stimuliResonance imaging studyBrain mechanismsIndividual differencesPrevention of depressionCircadian interventionsBrain responsesEmotional stabilityBehavioral therapyAnxiety severityBrain activityBrain responsivenessLeft insulaInsomnia disorderHigh riskInsomnia symptomsVolume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
Groenewold N, Bas-Hoogendam J, Amod A, Laansma M, Van Velzen L, Aghajani M, Hilbert K, Oh H, Salas R, Jackowski A, Pan P, Salum G, Blair J, Blair K, Hirsch J, Pantazatos S, Schneier F, Talati A, Roelofs K, Volman I, Blanco-Hinojo L, Cardoner N, Pujol J, Beesdo-Baum K, Ching C, Thomopoulos S, Jansen A, Kircher T, Krug A, Nenadić I, Stein F, Dannlowski U, Grotegerd D, Lemke H, Meinert S, Winter A, Erb M, Kreifelts B, Gong Q, Lui S, Zhu F, Mwangi B, Soares J, Wu M, Bayram A, Canli M, Tükel R, Westenberg P, Heeren A, Cremers H, Hofmann D, Straube T, Doruyter A, Lochner C, Peterburs J, Van Tol M, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Filippi C, Gold A, Harrewijn A, Zugman A, Bülow R, Grabe H, Völzke H, Wittfeld K, Böhnlein J, Dohm K, Kugel H, Schrammen E, Zwanzger P, Leehr E, Sindermann L, Ball T, Fonzo G, Paulus M, Simmons A, Stein M, Klumpp H, Phan K, Furmark T, Månsson K, Manzouri A, Avery S, Blackford J, Clauss J, Feola B, Harper J, Sylvester C, Lueken U, Veltman D, Winkler A, Jahanshad N, Pine D, Thompson P, Stein D, Van der Wee N. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Molecular Psychiatry 2023, 28: 1079-1089. PMID: 36653677, PMCID: PMC10804423, DOI: 10.1038/s41380-022-01933-9.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderSubcortical brain regionsAnxiety disordersSAD patientsBilateral putamen volumesSubcortical regionsBrain regionsLinear mixed effects analysisComorbid anxiety disordersSubcortical volumesFamily-wise errorPutamen volumeSAD onsetVolumetric differencesPallidum volumeMixed effects analysisD effect sizesInconsistent findingsLeft putamenEffect sizeFull samplePrevious findingsInternational sampleSignificant interactionLimited convergence
2022
Shared brain and genetic architectures between mental health and physical activity
Zhang W, Paul S, Winkler A, Bogdan R, Bijsterbosch J. Shared brain and genetic architectures between mental health and physical activity. Translational Psychiatry 2022, 12: 428. PMID: 36192376, PMCID: PMC9530213, DOI: 10.1038/s41398-022-02172-w.Peer-Reviewed Original ResearchConceptsPhysical activityMental healthConnectivity strengthPhysical activity measuresSelf-reported mental health measuresMental health measuresPhysical activity modelBrain network architectureLatent causal variable analysisAccelerometer-derived measuresHealth measuresActivity measuresBeneficial effectsBiological correlatesUK BiobankCausal relationshipBrain mechanismsNeural correlatesHealthLinkage disequilibrium score regressionSimilar loading patternsBrainPutative causal relationshipDisequilibrium score regressionForms of psychopathologytDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel
Nandi T, Puonti O, Clarke W, Nettekoven C, Barron H, Kolasinski J, Hanayik T, Hinson E, Berrington A, Bachtiar V, Johnstone A, Winkler A, Thielscher A, Johansen-Berg H, Stagg C. tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel. Brain Stimulation 2022, 15: 1153-1162. PMID: 35988862, PMCID: PMC7613675, DOI: 10.1016/j.brs.2022.07.049.Peer-Reviewed Original ResearchStructural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis
Bas-Hoogendam J, Bernstein R, Benson B, Buss K, Gunther K, Pérez-Edgar K, Salum G, Jackowski A, Bressan R, Zugman A, Degnan K, Filippi C, Fox N, Henderson H, Tang A, Zeytinoglu S, Harrewijn A, Hillegers M, White T, van IJzendoorn M, Schwartz C, Felicione J, DeYoung K, Shackman A, Smith J, Tillman R, van den Berg Y, Cillessen A, Roelofs K, Tyborowska A, Hill S, Battaglia M, Tettamanti M, Dougherty L, Jin J, Klein D, Leung H, Avery S, Blackford J, Clauss J, Hayden E, Liu P, Vandermeer M, Goldsmith H, Planalp E, Nichols T, Thompson P, Westenberg P, van der Wee N, Groenewold N, Stein D, Winkler A, Pine D, Group E. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: 1182-1188. PMID: 36038199, PMCID: PMC9434711, DOI: 10.1016/j.jaac.2022.04.023.Peer-Reviewed Original ResearchConceptsStructural brain correlatesSelf-report questionnairesTendency of individualsInhibited temperamentBehavioral inhibitionBrain correlatesUnfamiliar peopleDirect behavioral observationsEmotional tendencyTemperamentTemperament classificationEarly childhoodBehavioral observationsUnexpected eventsRetrospective levelsIndividualsUnfamiliarCorrelatesCaregiversTendencyRelateFirst yearChildhoodInfancyLifeSARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson J, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler A, Collins R, Matthews P, Allen N, Miller K, Nichols T, Smith S. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 2022, 604: 697-707. PMID: 35255491, PMCID: PMC9046077, DOI: 10.1038/s41586-022-04569-5.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pre-existing risk factorsSARS-CoV-2 infectionSARS-CoV-2 casesPrimary olfactory cortexGreater reductionUK BiobankGreater cognitive declineMagnetic resonance imagingGray matter thicknessLongitudinal effectsNeuroinflammatory eventsRisk factorsOlfactory cortexMild casesBrain changesBrain pathologyCOVID-191Parahippocampal gyrusBrain imaging resultsCognitive declineTissue damageResonance imagingOlfactory pathwayOrbitofrontal cortex
2021
Reassessing associations between white matter and behaviour with multimodal microstructural imaging
Lazari A, Salvan P, Cottaar M, Papp D, van der Werf O, Johnstone A, Sanders Z, Sampaio-Baptista C, Eichert N, Miyamoto K, Winkler A, Callaghan M, Nichols T, Stagg C, Rushworth M, Verhagen L, Johansen-Berg H. Reassessing associations between white matter and behaviour with multimodal microstructural imaging. Cortex 2021, 145: 187-200. PMID: 34742100, PMCID: PMC8940642, DOI: 10.1016/j.cortex.2021.08.017.Peer-Reviewed Original ResearchCortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
Harrewijn A, Cardinale E, Groenewold N, Bas-Hoogendam J, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski A, Pan P, Salum G, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo-Baum K, Jahanshad N, Thomopoulos S, Buckner R, Nielsen J, Smoller J, Soares J, Mwangi B, Wu M, Zunta-Soares G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton B, Benson B, Freitag G, Filippi C, Gold A, Leibenluft E, Ringlein G, Werwath K, Zwiebel H, Zugman A, Grabe H, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston N, Ernst M, Grillon C, Mujica-Parodi L, van Nieuwenhuizen H, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball T, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Sylvester C, Yu Q, Lueken U, Veltman D, Thompson P, Stein D, Van der Wee N, Winkler A, Pine D. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. Translational Psychiatry 2021, 11: 502. PMID: 34599145, PMCID: PMC8486763, DOI: 10.1038/s41398-021-01622-1.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderHealthy controlsBrain structuresMain analysisSecondary analysisAnxiety disordersMale healthy controlsVertex-wise cortical thicknessFemale healthy controlsRandom interceptGlobal brain measuresStructural magnetic resonanceCortical surface areaSubcortical brain structuresMedication useYears of educationCortical thicknessSubcortical volumesWorking GroupVentral diencephalonSmall sample sizeBrain measuresInconsistent findingsRight ventral diencephalonMale individuals
2020
Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth
Axelrud L, Simioni A, Pine D, Winkler A, Pan P, Sato J, Zugman A, Parker N, Picon F, Jackowski A, Hoexter M, Barker G, Martinot J, Martinot M, Satterthwaite T, Rohde L, Milham M, Barker E, Salum G. Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth. European Child & Adolescent Psychiatry 2020, 30: 1895-1906. PMID: 33030612, PMCID: PMC9077631, DOI: 10.1007/s00787-020-01653-x.Peer-Reviewed Original ResearchConceptsGeneral psychopathologyCortical thicknessBrain featuresSubcortical volumesMental disordersStructural brain featuresInternal consistencyBrain structural featuresHealthy Brain NetworkPsychiatric disordersAssociation scoreSymptomatic domainsHigh internal consistencyPsychopathology assessmentDisordersBrain networksLow internal consistencyEffect sizeBehavioral phenotypesScoresReplicable associationsPsychopathologyWeighted scoreAssociationReplicable markersUltra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain
Schulz E, Stankewitz A, Winkler A, Irving S, Witkovský V, Tracey I. Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain. ELife 2020, 9: e55028. PMID: 32876049, PMCID: PMC7498261, DOI: 10.7554/elife.55028.Peer-Reviewed Original ResearchConceptsPain attenuationBrain connectivityAttenuation of painCognitive strategiesHigher functional connectivityWhole-brain connectivityTonic cold painWhite matter integrityPain processingLower painFunctional imaging dataCold painPainCingulate cortexBrain regionsFunctional connectivityHealthy participantsTrialsCognitive interventionsDiffusion tensorTrial variabilityBrain dataImaging dataParticipantsPermutation inference for canonical correlation analysis
Winkler A, Renaud O, Smith S, Nichols T. Permutation inference for canonical correlation analysis. NeuroImage 2020, 220: 117065. PMID: 32603857, PMCID: PMC7573815, DOI: 10.1016/j.neuroimage.2020.117065.Peer-Reviewed Original ResearchThe effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure
Sexton C, Betts J, Dennis A, Doherty A, Leeson P, Holloway C, Dall'Armellina E, Winkler A, Demnitz N, Wassenaar T, Dawes H, Johansen-Berg H. The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure. Physiology & Behavior 2020, 223: 112923. PMID: 32474233, PMCID: PMC7378567, DOI: 10.1016/j.physbeh.2020.112923.Peer-Reviewed Original ResearchConceptsAerobic training programGray matter volumeCardiorespiratory fitnessMatter volumeMagnetic resonance imaging outcomesSpecific high-risk populationsBrain structuresOlder adultsAerobic training interventionHigh-risk populationStructural MRI analysisTract-based spatial statisticsVoxel-based morphometryVoxel-wise assessmentWaitlist control conditionHealthy older adultsWhite matter microstructureImaging outcomesHippocampal volumeObservational studyPhysical activityReduced riskCognitive declineMax testingMore encouraging resultsENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
Thompson PM, Jahanshad N, Ching CRK, Salminen LE, Thomopoulos SI, Bright J, Baune BT, Bertolín S, Bralten J, Bruin WB, Bülow R, Chen J, Chye Y, Dannlowski U, de Kovel CGF, Donohoe G, Eyler LT, Faraone SV, Favre P, Filippi CA, Frodl T, Garijo D, Gil Y, Grabe HJ, Grasby KL, Hajek T, Han LKM, Hatton SN, Hilbert K, Ho TC, Holleran L, Homuth G, Hosten N, Houenou J, Ivanov I, Jia T, Kelly S, Klein M, Kwon JS, Laansma MA, Leerssen J, Lueken U, Nunes A, Neill J, Opel N, Piras F, Piras F, Postema MC, Pozzi E, Shatokhina N, Soriano-Mas C, Spalletta G, Sun D, Teumer A, Tilot AK, Tozzi L, van der Merwe C, Van Someren EJW, van Wingen GA, Völzke H, Walton E, Wang L, Winkler AM, Wittfeld K, Wright MJ, Yun JY, Zhang G, Zhang-James Y, Adhikari BM, Agartz I, Aghajani M, Aleman A, Althoff RR, Altmann A, Andreassen OA, Baron DA, Bartnik-Olson BL, Marie Bas-Hoogendam J, Baskin-Sommers AR, Bearden CE, Berner LA, Boedhoe PSW, Brouwer RM, Buitelaar JK, Caeyenberghs K, Cecil CAM, Cohen RA, Cole JH, Conrod PJ, De Brito SA, de Zwarte SMC, Dennis EL, Desrivieres S, Dima D, Ehrlich S, Esopenko C, Fairchild G, Fisher SE, Fouche JP, Francks C, Frangou S, Franke B, Garavan HP, Glahn DC, Groenewold NA, Gurholt TP, Gutman BA, Hahn T, Harding IH, Hernaus D, Hibar DP, Hillary FG, Hoogman M, Hulshoff Pol HE, Jalbrzikowski M, Karkashadze GA, Klapwijk ET, Knickmeyer RC, Kochunov P, Koerte IK, Kong XZ, Liew SL, Lin AP, Logue MW, Luders E, Macciardi F, Mackey S, Mayer AR, McDonald CR, McMahon AB, Medland SE, Modinos G, Morey RA, Mueller SC, Mukherjee P, Namazova-Baranova L, Nir TM, Olsen A, Paschou P, Pine DS, Pizzagalli F, Rentería ME, Rohrer JD, Sämann PG, Schmaal L, Schumann G, Shiroishi MS, Sisodiya SM, Smit DJA, Sønderby IE, Stein DJ, Stein JL, Tahmasian M, Tate DF, Turner JA, van den Heuvel OA, van der Wee NJA, van der Werf YD, van Erp TGM, van Haren NEM, van Rooij D, van Velzen LS, Veer IM, Veltman DJ, Villalon-Reina JE, Walter H, Whelan CD, Wilde EA, Zarei M, Zelman V. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry 2020, 10: 100. PMID: 32198361, PMCID: PMC7083923, DOI: 10.1038/s41398-020-0705-1.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderPost-traumatic stress disorderAutism spectrum disorderObsessive-compulsive disorderDissociative identity disorderBrain systemsSubstance use disordersHyperactivity disorderSpectrum disorderStress disorderConduct disorderAnxiety disordersBrain metricsDiverse samplePsychosocial factorsIdentity disorderAntisocial personalityHuman brainSuicidal thoughtsUse disordersHarmonized analysesGender differencesRobustness of findingsNeuroscienceBrain injuryMultiple testing correction over contrasts for brain imaging
Alberton B, Nichols T, Gamba H, Winkler A. Multiple testing correction over contrasts for brain imaging. NeuroImage 2020, 216: 116760. PMID: 32201328, PMCID: PMC8191638, DOI: 10.1016/j.neuroimage.2020.116760.Peer-Reviewed Original ResearchWhite matter structure and myelin-related gene expression alterations with experience in adult rats
Sampaio-Baptista C, Vallès A, Khrapitchev A, Akkermans G, Winkler A, Foxley S, Sibson N, Roberts M, Miller K, Diamond M, Martens G, De Weerd P, Johansen-Berg H. White matter structure and myelin-related gene expression alterations with experience in adult rats. Progress In Neurobiology 2020, 187: 101770. PMID: 32001310, PMCID: PMC7086231, DOI: 10.1016/j.pneurobio.2020.101770.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingAdult ratsMRNA expressionMyelin basic protein mRNA expressionWM plasticityNeuronal activity modulationMBP protein expressionC-fos mRNA expressionMatter structuresAnalysis of myelinGray matter structuresProtein mRNA expressionWhite matter plasticityRegulation of myelinationWhite matter structuresBarrel cortexGene expression alterationsCortical activityMRNA expression analysisRNA sequencing analysisBrain structuresTensor imagingDTI differencesMacroscale measuresMolecular correlates
2019
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure
Abend R, Gold A, Britton J, Michalska K, Shechner T, Sachs J, Winkler A, Leibenluft E, Averbeck B, Pine D. Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure. Biological Psychiatry 2019, 87: 916-925. PMID: 31955915, PMCID: PMC7211142, DOI: 10.1016/j.biopsych.2019.11.006.Peer-Reviewed Original ResearchConceptsSkin conductance responsesConductance responsesBrain structuresThreat conditioningPathological anxietyComparison subjectsPsychophysiological responsesLarger patient samplesPrefrontal cortical thicknessHealthy comparison subjectsStructural magnetic resonance imaging (MRI) dataThreat stimuliAnticipatory respondingExtinction paradigmStimulus typeMagnetic resonance imaging dataWide age rangeCortical thicknessPatientsNeurodevelopmental changesAnticipatory responsesTranslational advancesStructural brainAdult populationPatient samples