2020
Emerging roles for noncoding RNAs in female sex steroids and reproductive disease
Zhang R, Wesevich V, Chen Z, Zhang D, Kallen AN. Emerging roles for noncoding RNAs in female sex steroids and reproductive disease. Molecular And Cellular Endocrinology 2020, 518: 110875. PMID: 32668269, PMCID: PMC7609472, DOI: 10.1016/j.mce.2020.110875.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleGonadal Steroid HormonesHumansInfertility, FemaleReproductionRNA, UntranslatedConceptsRole of ncRNAsSteroid hormone productionFemale gametogenesisNcRNA expressionRegulatory networksDNA blueprintNoncoding RNAsFunctional RNAsCentral dogmaNcRNAsBiological processesMolecular biologyRNAMessenger RNAParticular disease stateHormone productionSex steroid hormone productionCritical roleProteinTherapeutic targetReproductive pathologiesPotential diagnostic markerPolycystic ovary syndromeReproductive diseasesFemale sex steroidsThe relationship between H19 and parameters of ovarian reserve
Xia X, Burn MS, Chen Y, Karakaya C, Kallen A. The relationship between H19 and parameters of ovarian reserve. Reproductive Biology And Endocrinology 2020, 18: 46. PMID: 32404103, PMCID: PMC7218823, DOI: 10.1186/s12958-020-00578-z.Peer-Reviewed Original ResearchConceptsOvarian reserveDecreased ovarian reserveOocyte retrievalH19 expressionInfertility evaluationCumulus cellsTransvaginal oocyte retrievalDiminished ovarian reserveAnti-Mullerian hormoneDownregulation of H19H19 expression levelsGazi University SchoolParticipantsA totalAMH levelsSerum AMHIVF patientsOocyte yieldLow respondersBlood samplesNovel biomarkersExpression levelsFurther studiesPatientsUniversity SchoolH19
2015
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells
Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.Peer-Reviewed Original ResearchConceptsIVF-intracytoplasmic sperm injectionMiR-21-5p expressionPoor respondersMiR-21-5pMiR-21-3pCumulus cellsHuman granulosa-like tumor cellsMicro-ribonucleic acid (miRNA) expressionMiR-21-3p expressionLower serum E2 levelsMiR-21Elevated expressionPoor ovarian responseSerum E2 levelsReverse transcription real-time polymerase chain reactionTranscription real-time polymerase chain reactionNumber of oocytesLower E2 concentrationsAcademic medical centerReal-time polymerase chain reactionRespective age groupsMicroRNA microarray analysisOvarian responseAltered miRNA expressionE2 levelsBlood type predicts live birth in the infertile population
Goldsammler M, Jindal SK, Kallen A, Mmbaga N, Pal L. Blood type predicts live birth in the infertile population. Journal Of Assisted Reproduction And Genetics 2015, 32: 551-555. PMID: 25701141, PMCID: PMC4380903, DOI: 10.1007/s10815-015-0441-2.Peer-Reviewed Original ResearchConceptsIVF cycle outcomesIU/LLive birthsBlood type ABlood type BBlood typeBaseline FSHInfertile womenCycle outcomeMultivariable logistic regression analysisIVF cycle parametersBlood type OPatient's blood typeType BLogistic regression analysisType AType OOvulatory infertilityPatient characteristicsIVF outcomesMethodsRetrospective studyInfertile populationHigher oddsAcademic centersInfertility