2024
Association of Undernutrition With Mortality and Amputation Outcomes in Chronic Limb Threatening Ischaemia: A Systematic Review
Scierka L, Cleman J, Brice A, Grimshaw A, Soedamah-Muthu S, Mena-Hurtado C, Smolderen K. Association of Undernutrition With Mortality and Amputation Outcomes in Chronic Limb Threatening Ischaemia: A Systematic Review. European Journal Of Vascular And Endovascular Surgery 2024 PMID: 39216793, DOI: 10.1016/j.ejvs.2024.08.038.Peer-Reviewed Original ResearchChronic limb-threatening ischaemiaNutritional screening toolsLimb-threatening ischaemiaRisk of deathValidity of nutrition screening toolsSystematic reviewScreening toolEffect sizeStatistically significant increased riskNutritional statusIndicators of undernutritionModifiable risk factorsStatistically significant increased risk of deathRandomised controlled trialsQuality of evidenceCertainty of evidenceNutritional status measuresIncreased risk of deathCase-control studySystematic literature searchAmputation outcomesStatus measuresCase-control study of patientsData extractionCohort studySystematic review: The use of large language models as medical chatbots in digestive diseases
Giuffrè M, Kresevic S, You K, Dupont J, Huebner J, Grimshaw A, Shung D. Systematic review: The use of large language models as medical chatbots in digestive diseases. Alimentary Pharmacology & Therapeutics 2024, 60: 144-166. PMID: 38798194, DOI: 10.1111/apt.18058.Peer-Reviewed Original ResearchLanguage modelAdverse patient safety eventsPatient safety eventsClinical decision supportRisk of biasSystematic literature searchWeb of Science Core CollectionCombination of keywordsMedical chatbotTriage recommendationsHealthcare systemScience Core CollectionNecessary careSafety eventsOverburden healthcare systemsMedical adviceOvid MEDLINEMultiple specialtiesDecision supportOvid EmbaseCochrane LibrarySingle-study resultsGoogle ScholarLiterature searchGastroenterology
2023
Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis
Carey G, Holleck J, Alshaeba S, Jayakrishnan R, Gordon K, Grimshaw A, Gunderson C. Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis. Journal Of Antimicrobial Chemotherapy 2023, 78: 1150-1159. PMID: 36964648, DOI: 10.1093/jac/dkad078.Peer-Reviewed Original ResearchConceptsCommon infectious syndromesEmpirical antibioticsPrevalence of MRSAInfectious syndromesMRSA infectionIll patientsMortality rateSystematic reviewAbsolute mortality benefitAnti-MRSA therapyEmpirical antibiotic coverageLow-risk infectionsSoft tissue infectionsUrinary tract infectionAbsolute risk reductionMethicillin-resistant Staphylococcus aureusCatheter-related infectionsStudy of patientsBaseline mortality ratesSystematic literature searchWeb of ScienceMRSA coverageAntibiotic coverageEmpirical antimicrobialsMortality benefit
2021
Risk of Intestinal Necrosis With Sodium Polystyrene Sulfonate: A Systematic Review and Meta‐analysis
Holleck JL, Roberts AE, Marhoffer EA, Grimshaw AA, Gunderson CG. Risk of Intestinal Necrosis With Sodium Polystyrene Sulfonate: A Systematic Review and Meta‐analysis. Journal Of Hospital Medicine 2021, 16: 489-494. PMID: 34328838, DOI: 10.12788/jhm.3655.Peer-Reviewed Original ResearchConceptsSevere gastrointestinal side effectsGastrointestinal side effectsIntestinal necrosisHazard ratioSide effectsComposite outcomeOdds ratioSodium polystyrene sulfonateSystematic reviewSevere gastrointestinal adverse eventsGastrointestinal adverse eventsPooled hazard ratioRisk of biasPooled odds ratioCase-control studyPrior systematic reviewsSystematic literature searchAdverse eventsAlternative medicationsCochrane LibraryDatabase inceptionClinical trialsNecrosis rateInclusion criteriaPotential confoundingEffect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta‐analysis
Kir D, Shapero K, Chatterjee S, Grimshaw A, Oddleifson A, Spatz ES, Goldsweig AM, Desai NR. Effect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta‐analysis. Catheterization And Cardiovascular Interventions 2021, 98: e453-e461. PMID: 33565695, DOI: 10.1002/ccd.29502.Peer-Reviewed Original ResearchConceptsLow-volume centersVolume centersTitles/abstractsPatient outcomesTAVR centersTAVR volumeCause mortalitySystematic reviewHigh-volume centersIntermediate-volume centersReplacement volumeFull-text studiesCause mortality dataStrong referral networkFree-text termsSystematic literature searchPre-specified criteriaEligible studiesProcedural volumeExclusion criteriaMortality rateTAVRLiterature searchMortality dataRelevant articles
2020
Prevalence of harmful diagnostic errors in hospitalised adults: a systematic review and meta-analysis
Gunderson CG, Bilan VP, Holleck JL, Nickerson P, Cherry BM, Chui P, Bastian LA, Grimshaw AA, Rodwin BA. Prevalence of harmful diagnostic errors in hospitalised adults: a systematic review and meta-analysis. BMJ Quality & Safety 2020, 29: 1008-1018. PMID: 32269070, DOI: 10.1136/bmjqs-2019-010822.Peer-Reviewed Original ResearchConceptsAdverse eventsDiagnostic errorsPhysician reviewSystematic reviewInpatient adverse eventsRisk of biasPatient safety hazardsSystem-related factorsSystematic literature searchWeb of SciencePulmonary embolismAdult patientsCase seriesCommon diagnosisPooled rateAdult admissionsCochrane LibraryDatabase inceptionDiagnostic error rateStudy characteristicsLiterature searchPatientsCommon diseaseDiagnosisCommon beingRate of Preventable Mortality in Hospitalized Patients: a Systematic Review and Meta-analysis
Rodwin BA, Bilan VP, Merchant NB, Steffens CG, Grimshaw AA, Bastian LA, Gunderson CG. Rate of Preventable Mortality in Hospitalized Patients: a Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2020, 35: 2099-2106. PMID: 31965525, PMCID: PMC7351940, DOI: 10.1007/s11606-019-05592-5.Peer-Reviewed Original ResearchConceptsInpatient deathPreventable mortalityPreventable deathsMortality rateHospital mortality rateLife expectancyRandom-effects modelSystematic literature searchNumber of deathsWeb of ScienceHospital deathAdult patientsHospitalized patientsResultsSixteen studiesCase seriesPooled rateCochrane LibraryInclusion criteriaPatientsMeta-AnalysisSystematic reviewLiterature searchData extractionMortalityDeath