2016
Biochemical Screening for Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia
Montgomery AM, Bazzy-Asaad A, Asnes JD, Bizzarro MJ, Ehrenkranz RA, Weismann CG. Biochemical Screening for Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia. Neonatology 2016, 109: 190-194. PMID: 26780635, DOI: 10.1159/000442043.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasiaPulmonary hypertensionGestational ageNT-proBNPBirth weightBiochemical markersPreterm infantsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptidePresence of PHCross-sectional pilot studyNitric oxideWeeks gestational ageSuch biochemical markersEchocardiographic evidenceScreening echocardiogramsWeeks CGANatriuretic peptideCitrulline levelsInfantsArginine levelsPrecursor citrullineLarger studyEchocardiogramPilot study
2014
Association between right ventricular dysfunction and restrictive lung disease in childhood cancer survivors as measured by quantitative echocardiography
Patel A, Weismann C, Weiss P, Russell K, Bazzy‐Asaad A, Kadan‐Lottick N. Association between right ventricular dysfunction and restrictive lung disease in childhood cancer survivors as measured by quantitative echocardiography. Pediatric Blood & Cancer 2014, 61: 2059-2064. PMID: 25130668, DOI: 10.1002/pbc.25157.Peer-Reviewed Original ResearchConceptsRestrictive lung diseaseChildhood cancer survivorsLung diseaseCancer survivorsIsovolumetric accelerationRV dysfunctionRV functionVentricular dysfunctionMean ageTricuspid annular plane systolic excursionQuantitative echocardiographyAnnular plane systolic excursionEarly RV dysfunctionLower tissue DopplerRestrictive pulmonary impairmentSubclinical RV dysfunctionRight ventricular dysfunctionLeft ventricular dysfunctionPulmonary function testsRight ventricular functionParticipants' mean ageMeasures of contractilityLarger study populationLymphoma/leukemiaThoracic radiation
2011
Unusual pulmonary findings in mucolipidosis II
Ishak M, Zambrano EV, Bazzy‐Asaad A, Esquibies AE. Unusual pulmonary findings in mucolipidosis II. Pediatric Pulmonology 2011, 47: 719-721. PMID: 22162509, DOI: 10.1002/ppul.21599.Peer-Reviewed Original Research
2010
Utilization of a second caregiver in the care of a child with a tracheostomy in the homecare setting
Tolomeo C, Bazzy‐Asaad A. Utilization of a second caregiver in the care of a child with a tracheostomy in the homecare setting. Pediatric Pulmonology 2010, 45: 656-660. PMID: 20578067, DOI: 10.1002/ppul.21233.Peer-Reviewed Original ResearchConceptsTracheostomy tubeSecond caregiverDischarge databaseCaregiver participationMedical/nursing careCaregiver responsesGuardians/parentsParents/guardiansUnivariate analysisNursing careAnticipatory guidanceRespite servicesHomecare settingPrimary caregiversPilot studyHome settingCaregiversSecondary caregiversConvenience sampleCareChildrenInfantsSpecial training programsTraining programHomePulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia
Esquibies AE, Zambrano E, Ziai J, Kesebir D, Touloukian RJ, Egan ME, Reyes‐Múgica M, Bazzy‐Asaad A. Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia. Pediatric Pulmonology 2010, 45: 202-204. PMID: 20054858, DOI: 10.1002/ppul.21148.Peer-Reviewed Original Research
2009
Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease
Pashankar FD, Carbonella J, Bazzy‐Asaad A, Friedman A. Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease. British Journal Of Haematology 2009, 144: 736-741. PMID: 19055665, DOI: 10.1111/j.1365-2141.2008.07501.x.Peer-Reviewed Original ResearchConceptsTricuspid regurgitant jet velocityElevated pulmonary artery pressurePulmonary artery pressureSickle cell diseaseArtery pressureCell diseaseHigher tricuspid regurgitant jet velocityObstructive sleep apneaRegurgitant jet velocityRight ventricular pressureLowest oxygen saturationBorderline elevationCardiopulmonary evaluationInitial echocardiogramRepeat echocardiogramPulmonary hypertensionLower hemoglobinSleep apneaPersistent elevationRisk factorsVentricular pressureIntrapatient variabilityOxygen saturationEchocardiogramPatients
2008
Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure. Pediatrics 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep-disordered breathingSympathetic nervous system activityPositive airway pressureNervous system activityWhole-body insulin sensitivityMetabolic syndromeAirway pressureLeptin levelsInsulin sensitivitySystem activityExact testContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentC-reactive protein levelsOral glucose tolerance testGlucose tolerance testRole of leptinBMI z-scoreFisher's exact testOvernight polysomnographyBreathing groupMetabolic derangementsInsulin resistanceSleep QuestionnairePrevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease
Pashankar FD, Carbonella J, Bazzy-Asaad A, Friedman A. Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease. Pediatrics 2008, 121: 777-782. PMID: 18381543, DOI: 10.1542/peds.2007-0730.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionAnemia, Sickle CellChildChild, PreschoolCohort StudiesComorbidityFemaleFollow-Up StudiesHumansHypertension, PulmonaryMaleMass ScreeningPrevalenceProspective StudiesPulmonary Wedge PressureRisk AssessmentSeverity of Illness IndexSex DistributionSurvival AnalysisTricuspid Valve InsufficiencyUltrasonography, Doppler, TranscranialConceptsTricuspid regurgitant jet velocityElevated pulmonary artery pressureElevated tricuspid regurgitant jet velocityPulmonary artery pressureRegurgitant jet velocityTranscranial Doppler examinationArtery pressurePulmonary hypertensionDoppler examinationSickle cell diseaseRisk factorsCell diseaseExact testPeak tricuspid regurgitant jet velocityPulmonary artery systolic pressureHigh pulmonary artery pressureComprehensive clinic visitModerate pulmonary hypertensionRight outflow obstructionAcute chest syndromeMild pulmonary hypertensionPercent of patientsChronic blood transfusionsHigher platelet countsLowest oxygen saturation
2007
δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia
Chao D, Bazzy‐Asaad A, Balboni G, Xia Y. δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. Journal Of Cellular Physiology 2007, 212: 60-67. PMID: 17373650, DOI: 10.1002/jcp.21000.Peer-Reviewed Original ResearchConceptsMicro-opioid receptorOxygen-glucose deprivationOpioid receptorsDelta-opioid receptor activationHypoxic/ischemic stressPresence of paxillineHypoxia-induced increaseH-Dmt-TicDOR activityDOR antagonistDOR agonistsCortical slicesAcute hypoxiaMOR agonistsChannel blockersDOR effectsIschemic stressDerangementReceptor activationCortexDADLEReceptorsUnderlying mechanismChannel activityAgonists