2023
Increasing sensitivity of antibody-antigen interactions using photo-cross-linking
de la Peña A, Sewall L, de Paiva Froes Rocha R, Jackson A, Pratap P, Bangaru S, Cottrell C, Mohanty S, Shaw A, Ward A. Increasing sensitivity of antibody-antigen interactions using photo-cross-linking. Cell Reports Methods 2023, 3: 100509. PMID: 37426749, PMCID: PMC10326447, DOI: 10.1016/j.crmeth.2023.100509.Peer-Reviewed Original ResearchConceptsPolyclonal immune responseImmune responseTime pointsRational vaccine designLater time pointsEarly time pointsVaccine immunogensAnimal modelsAntibody detectionVaccine designIntermediate antibodiesEarly timepointsLater timepointsAntibodiesViral glycoproteinsTimepointsDifferent viral glycoproteinsSensitivity of detectionAntibody-antigen interactionsResponsePatientsVaccination
2015
Paradoxical changes in innate immunity in aging: recent progress and new directions
Montgomery RR, Shaw AC. Paradoxical changes in innate immunity in aging: recent progress and new directions. Journal Of Leukocyte Biology 2015, 98: 937-943. PMID: 26188078, PMCID: PMC4661037, DOI: 10.1189/jlb.5mr0315-104r.Peer-Reviewed Original ResearchConceptsImmune responseInnate immune changesInnate immune responseCytokine levelsInappropriate elevationImmune changesNaïve cell populationT cellsAdaptive immunityViral infectionParadoxical increaseInnate immunityMultiple cell typesParadoxical changesCell populationsActivation stateImmunityCell typesSevere consequencesResponseTissue contextImmunosenescenceVaccinationPopulationInfection