2024
Beyond antiviral: role of IFN-I in brain development
Baker C, Iwasaki A. Beyond antiviral: role of IFN-I in brain development. Trends In Immunology 2024, 45: 322-324. PMID: 38644134, DOI: 10.1016/j.it.2024.04.004.Commentaries, Editorials and LettersMeSH KeywordsAnimalsBrainHumansInterferon Type IMiceMicrogliaNeuronal PlasticityNeuronsPhagocytosisSignal Transduction
2021
Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus
Tokuyama M, Gunn BM, Venkataraman A, Kong Y, Kang I, Rakib T, Townsend MJ, Costenbader KH, Alter G, Iwasaki A. Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus. Journal Of Experimental Medicine 2021, 218: e20191766. PMID: 34019642, PMCID: PMC8144942, DOI: 10.1084/jem.20191766.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusImmune complexesFormation of NETsEnvelope proteinSLE patient bloodInnate immune activationImmune complex formationActivate neutrophilsInterferon statusAutoantibody levelsIgG levelsHigher interferonImmune activationNeutrophil phagocytosisSLE IgGNeutrophil activationExtracellular trapsSLE plasmaNeutrophil elastasePatient's bloodErythematosusNeutrophilsPhagocytosis
2012
Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes
Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA. Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes. Immunity 2012, 37: 986-997. PMID: 23219390, PMCID: PMC3786711, DOI: 10.1016/j.immuni.2012.09.014.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Adaptor protein 3Plasmacytoid dendritic cellsDNA-containing immune complexesI interferonPathogenic DNAMicrotubule-associated proteinsType I interferon secretionIFN-α productionDNA immune complexesPreinitiation complexType I interferonAnti-DNA autoantibodiesNoncanonical autophagyAutophagic pathwayHost DNADendritic cellsAutoimmune disordersReceptor 9Interferon secretionChain 3Immune complexesProtein 3DNAInterferonPhagosome as the Organelle Linking Innate and Adaptive Immunity
Kagan JC, Iwasaki A. Phagosome as the Organelle Linking Innate and Adaptive Immunity. Traffic 2012, 13: 1053-1061. PMID: 22577865, PMCID: PMC3658133, DOI: 10.1111/j.1600-0854.2012.01377.x.Peer-Reviewed Original ResearchConceptsProcess of phagocytosisPhagosome traffickingAdaptive immunityAntimicrobial defense mechanismsDefinable unitSubcellular levelT cell-mediated immunityAdaptive immune systemDefense mechanismsToll-like receptorsPhagosomesPhagocytosisImmune systemImmunityMicrobesTraffickingAutophagyPathwayReceptorsInnateAdaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-like Receptor Signaling and Antigen Presentation to CD4+ T Cells
Mantegazza AR, Guttentag SH, El-Benna J, Sasai M, Iwasaki A, Shen H, Laufer TM, Marks MS. Adaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-like Receptor Signaling and Antigen Presentation to CD4+ T Cells. Immunity 2012, 36: 782-794. PMID: 22560444, PMCID: PMC3361531, DOI: 10.1016/j.immuni.2012.02.018.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Protein Complex 3AnimalsAntigen PresentationAntigensCD4-Positive T-LymphocytesCell DifferentiationCell MembraneCells, CulturedDendritic CellsEndocytosisHistocompatibility Antigens Class IILigandsListeria monocytogenesListeriosisMiceMice, Inbred C57BLMice, TransgenicMyeloid Differentiation Factor 88OvalbuminPeptidesPhagocytosisPhagosomesSignal TransductionTh1 CellsToll-Like ReceptorsConceptsToll-like receptor signalingDendritic cellsAntigen presentationAdaptor protein 3Protein 3Receptor signalingMHC-II presentationEffector cell functionListeria monocytogenes infectionTLR ligandsMonocytogenes infectionTLR4 recruitmentT cellsCell activationIntracellular storesPhagolysosome maturationCell functionPearl miceReceptor-mediated endocytosisAntigenPresentationMolecular mechanismsPhagosomesCell surfaceSignaling
2009
Inflammasomes in viral infection
Ichinohe T, Iwasaki A. Inflammasomes in viral infection. Uirusu 2009, 59: 13. PMID: 19927984, DOI: 10.2222/jsv.59.13.Peer-Reviewed Original ResearchConceptsNOD-like receptorsProinflammatory cytokine interleukin-1betaRole of inflammasomesInfluenza virus infectionCytokine interleukin-1betaInnate immune responseCaspase-1 activationIL-33IL-18NLRP3 inflammasomeVirus infectionImmune responseInterleukin-1betaAdaptive immunityInflammasome activationMicrobial motifsDamage-associated signalsViral infectionInflammasomeMultiprotein complexesAdaptor proteinInfectionCertain virusesCell deathIntracellular sensors