2024
Endovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Endovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly. American Journal Of Neuroradiology 2024, ajnr.a8473. PMID: 39181691, DOI: 10.3174/ajnr.a8473.Peer-Reviewed Original ResearchPropensity score matchingBasilar artery occlusionIntracranial hemorrhageAssociated with higher ratesIn-hospital mortalityEndovascular thrombectomyIntravenous thrombolysisMedical managementAssociated with increased risk of ICHTreated with medical managementPatients treated with endovascular thrombectomyRisk of intracranial hemorrhageSafety of endovascular thrombectomyBasilar artery occlusion strokeFavorable hospital outcomesTreated with intravenous thrombolysisHome dischargeAssociated with increased riskEndovascular thrombectomy groupArtery occlusion strokeNational Inpatient SampleNIH Stroke ScalePropensity score-matched controlsStroke patientsHigher ratesTime-driven activity-based costing (TDABC) of direct-to-angiography pathway for acute ischemic stroke patients with suspected large vessel occlusion
Sangha K, White T, Boltyenkov A, Bastani M, Sanmartin M, Katz J, Malhotra A, Rula E, Naidich J, Sanelli P. Time-driven activity-based costing (TDABC) of direct-to-angiography pathway for acute ischemic stroke patients with suspected large vessel occlusion. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107516. PMID: 38183964, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107516.Peer-Reviewed Original ResearchAcute ischemic strokeEndovascular treatmentAcute ischemic stroke patientsAppropriate patient selection criteriaNovel care pathwayIschemic stroke patientsLarge vessel occlusionPatient selection criteriaInstitutional patient databaseTime-driven activity-based costingEligible patientsAnterior circulationIschemic strokeClinical outcomesPatient factorsStroke patientsAIS patientsVessel occlusionCare pathwayPatient costsMain cost driversPatientsPatient databaseAngiography suiteCT pathway
2023
O-007 Bridging thrombolysis yields diminished benefit among elderly stroke patients treated with endovascular thrombectomy
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. O-007 Bridging thrombolysis yields diminished benefit among elderly stroke patients treated with endovascular thrombectomy. 2023, a6-a7. DOI: 10.1136/jnis-2023-snis.7.Peer-Reviewed Original ResearchFactors associated with door-in-door-out times in large vessel occlusion stroke patients undergoing endovascular therapy
Radmard M, Wu X, Khunte M, Malhotra A. Factors associated with door-in-door-out times in large vessel occlusion stroke patients undergoing endovascular therapy. The American Journal Of Emergency Medicine 2023, 70: 192-193. PMID: 37393131, DOI: 10.1016/j.ajem.2023.06.020.Peer-Reviewed Original Research
2022
Cost-effectiveness of endovascular thrombectomy in acute stroke patients with large ischemic core
Sanmartin M, Katz J, Wang J, Malhotra A, Sangha K, Bastani M, Martinez G, Sanelli P. Cost-effectiveness of endovascular thrombectomy in acute stroke patients with large ischemic core. Journal Of NeuroInterventional Surgery 2022, 15: e166-e171. PMID: 36175016, DOI: 10.1136/jnis-2022-019460.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsIncremental cost-effectiveness ratioNet monetary benefitProbabilistic sensitivity analysesEconomic evaluation studiesCost-effectiveness analysisCost-effectiveness ratioSensitivity analysisTwo-way sensitivity analysesLifetime healthcare costsMonetary benefitsLife yearsLifetime costsLifetime benefitsLarge ischemic coreStandard careCost-effective strategyEVTIschemic coreStroke patientsAIS patientsPatient's lifetimeAcute ischemic stroke patientsCostEndovascular thrombectomy treatment
2020
Assessment of Intracranial Atherosclerotic Plaques Using 3D Black‐Blood MRI: Comparison With 3D Time‐of‐Flight MRA and DSA
Tian X, Tian B, Shi Z, Wu X, Peng W, Zhang X, Malhotra A, Mossa‐Basha M, Sekhar L, Liu Q, Lu J, Hu C, Zhu C. Assessment of Intracranial Atherosclerotic Plaques Using 3D Black‐Blood MRI: Comparison With 3D Time‐of‐Flight MRA and DSA. Journal Of Magnetic Resonance Imaging 2020, 53: 469-478. PMID: 32864816, DOI: 10.1002/jmri.27341.Peer-Reviewed Original ResearchConceptsTransient ischemic attackDigital subtraction angiographyMagnetic resonance angiographyPosterior circulation strokeInterclass correlation coefficientDegree of stenosisBlack blood MRINonstenotic plaquesIntracranial stenosisPlaque assessmentIntracranial vessel wall imagingIschemic stroke patientsIntracranial artery stenosisIntracranial atherosclerotic plaquesFlight magnetic resonance angiographyMann-Whitney U testAtherosclerotic plaque assessmentStage 2 J. MagnT-testStudent's t-testVessel wall imagingIschemic attackCohort studyArtery stenosisStroke patientsImplications of achieving TICI 2b vs TICI 3 reperfusion in patients with ischemic stroke: a cost-effectiveness analysis
Wu X, Khunte M, Gandhi D, Matouk C, Hughes DR, Sanelli P, Malhotra A. Implications of achieving TICI 2b vs TICI 3 reperfusion in patients with ischemic stroke: a cost-effectiveness analysis. Journal Of NeuroInterventional Surgery 2020, 12: 1161-1165. PMID: 32457225, DOI: 10.1136/neurintsurg-2020-015873.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsLarge vessel occlusionTICI 3 reperfusionEndovascular thrombectomyTICI 2bTICI 3Stroke patientsHealth benefitsAge groupsAcute stroke patientsDegree of recanalizationDegree of reperfusionLifetime quality-adjusted life yearsCost-effectiveness analysisDecision analytic studyUnited States settingsIncomplete reperfusionIschemic strokeComplete reperfusionPatient selectionReperfusionPatientsHealth outcomesLife yearsCost savings
2019
Higher Plaque Burden of Middle Cerebral Artery Is Associated With Recurrent Ischemic Stroke
Ran Y, Wang Y, Zhu M, Wu X, Malhotra A, Lei X, Zhang F, Wang X, Xie S, Zhou J, Zhu J, Cheng J, Zhu C. Higher Plaque Burden of Middle Cerebral Artery Is Associated With Recurrent Ischemic Stroke. Stroke 2019, 51: 659-662. PMID: 31856694, DOI: 10.1161/strokeaha.119.028405.Peer-Reviewed Original ResearchConceptsRecurrent ischemic strokeMiddle cerebral arteryMagnetic resonance vessel wall imagingPlaque burdenIschemic strokeVessel wall imagingAcute strokeCerebral arteryRecurrent strokeChronic strokeStroke patientsPlaque characteristicsMiddle cerebral artery plaqueRecurrent acute strokeRecurrent stroke groupRecurrent stroke patientsAcute stroke patientsHigher plaque burdenMethods One hundredDegree of stenosisClinical factorsStroke groupArtery plaquesFemale sexImaging featuresPND77 IMPACT OF THE INTERHOSPITAL TRANSFER TIME ON THE CLINICAL OUTCOMES OF ACUTE STROKE PATIENTS TREATED WITH MECHANICAL THROMBECTOMY
Boltyenkov A, Wang J, Martinez M, Adinarayan K, Hoang A, Malhotra A, Sanelli P. PND77 IMPACT OF THE INTERHOSPITAL TRANSFER TIME ON THE CLINICAL OUTCOMES OF ACUTE STROKE PATIENTS TREATED WITH MECHANICAL THROMBECTOMY. Value In Health 2019, 22: s751. DOI: 10.1016/j.jval.2019.09.1847.Peer-Reviewed Original ResearchA comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness
Hanna J, Malhotra A, Brauer PR, Luryi A, Michaelides E. A comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness. American Journal Of Otolaryngology 2019, 40: 102263. PMID: 31358317, DOI: 10.1016/j.amjoto.2019.07.007.Peer-Reviewed Original ResearchConceptsBenign paroxysmal positional vertigoStroke risk factorsCT/CTAEmergency departmentBPPV patientsNeurologic symptomsStroke patientsRisk factorsPositional vertigoCT headExam findingsNeurologic exam findingsPosterior circulation strokeProfile of patientsBenign positional vertigoParoxysmal positional vertigoCommon imaging modalityAcute strokeNeurologic examInitial imagingMRI brainDischarge diagnosisComputed tomographyPatientsVertigoCulprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: A systematic review
Wang Y, Liu X, Wu X, Degnan AJ, Malhotra A, Zhu C. Culprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: A systematic review. Atherosclerosis 2019, 287: 112-121. PMID: 31254918, PMCID: PMC6707846, DOI: 10.1016/j.atherosclerosis.2019.06.907.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsVessel wall MRISubstantial stenosisIschemic strokeStroke patientsMagnetic resonance angiographyIntracranial plaquesPlaque featuresAtherosclerotic plaquesSystematic reviewHigh-resolution vessel wall MRIHigh-risk plaque featuresAcute ischemic stroke patientsProgressive motor deficitsAcute ischemic strokeIntracranial atherosclerotic plaquesOverall functional outcomeHigh-risk plaquesRelevant clinical dataArterial atherosclerotic plaquesArticle reference listsAcute strokeCulprit plaquesIntracranial atherosclerosisMotor deficitsComparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients
Malhotra A, Wu X, Payabvash S, Matouk CC, Forman HP, Gandhi D, Sanelli P, Schindler J. Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients. Stroke 2019, 50: 963-969. PMID: 30908156, DOI: 10.1161/strokeaha.119.025031.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsIntravenous thrombolysisEndovascular thrombectomyLarge vessel occlusionAge 80 yearsEVT strategyVessel occlusionModified Rankin Scale scorePoststroke functional outcomeAcute ischemic strokeRankin Scale scoreElderly stroke patientsMarkov decision-analytic modelYears of ageDecision analytic modelMultiple sensitivity analysesPurpose- StrokeAcute strokeBaseline disabilityElderly patientsIschemic strokeStroke patientsFunctional outcomeHealthy patientsAdvanced age