Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis
Zhou Y, Zhao Y, Carbonaro M, Chen H, Germino M, Adler C, Ni M, Zhu Y, Kim S, Altarejos J, Li Z, Burczynski M, Glass D, Sleeman M, Lee A, Halasz G, Cheng X. Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis. Metabolism 2024, 154: 155830. PMID: 38428673, DOI: 10.1016/j.metabol.2024.155830.Peer-Reviewed Original ResearchWnt target genesWnt signalingGene expressionActivate gene expressionLiver zonationAlteration of Wnt signalingMouse NASH modelNon-alcoholic steatohepatitisSuppress gene expressionGene expression levelsNon-alcoholic steatohepatitis liversWnt regulationMetabolic pathwaysMetabolic zonationGenesRSPO3 expressionSpatial transcriptomicsIn situ hybridizationSpatial expressionExpression levelsRSPO3Perivenous hepatocytesMouse model of non-alcoholic steatohepatitisZonationModel of non-alcoholic steatohepatitis