2006
In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients
Tobiásová Z, Pospíšilová D, Miller A, Minárik I, Sochorová K, Špíšek R, Rob L, Bartůňková J. In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients. Clinical Immunology 2006, 122: 18-27. PMID: 17059893, DOI: 10.1016/j.clim.2006.09.003.Peer-Reviewed Original ResearchConceptsOvarian cancer patientsCancer patientsDendritic cellsAutologous irradiated tumor cellsLymphocyte IFN-gamma productionTumor cellsAntigen-pulsed DCsIFN-gamma ELISPOTMonocyte-derived DCsMaturation of DCsIrradiated tumor cellsIFN-gamma productionNew treatment optionsAbility of DCsResidual tumour diseaseProliferation of lymphocytesApoptotic tumor cellsTumor cell apoptosisDC vaccinesAutologous lymphocytesLymphocyte responsesStandard treatmentTreatment optionsOvarian cancerPatients
2005
Methods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children
Pospíšilová D, Borovičková J, Rožková D, Stary J, Seifertová D, Tobiásová Z, Špišek R, Bartůnková J. Methods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children. Medical Oncology 2005, 22: 79-88. PMID: 15750200, DOI: 10.1385/mo:22:1:079.Peer-Reviewed Original ResearchConceptsDendritic cellsPeripheral mononuclear cellsAcute lymphoblastic leukemiaMononuclear cellsCostimulatory moleculesBone marrow leukemic blastsPreparation of DCsPeripheral blood mononuclear cellsDendritic cell preparationsSpecific cytotoxic lymphocytesTime of remissionTime of diagnosisMature dendritic cellsBlood mononuclear cellsEfficiency of immunotherapyAutologous lymphocyte proliferationHematopoietic malignant cellsEvidence of inductionInduction chemotherapyBM blastsPediatric patientsCell immunotherapyB-ALLLymphoblastic leukemiaLeukemic blasts
2004
Immunotherapy--perspectives in therapy of ovarian carcinomas.
Zapletalová K, Tobiasová Z, Spísek R, Rob L, Bartůnková J. Immunotherapy--perspectives in therapy of ovarian carcinomas. Česká Gynekologie 2004, 69: 372-5. PMID: 15587893.Peer-Reviewed Original ResearchConceptsUniversity Hospital MotolMonoclonal antibody therapyCytokine therapyAntibody therapyMalignant ovarian epithelial tumorsCombination of surgeryDepartment of GynecologyOvarian cancer patientsOvarian epithelial tumorsDendritic cellsVaccine therapyMedical FacultyCancer patientsIL-2Clinical studiesTherapeutic protocolsEpithelial tumorsTherapyGM-CSFImmunotherapyTumor cellsMotolChemotherapySurgeryUsual standard