2022
Dosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy
Tien CJ, Damast S, Chen ZJ. Dosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy. Brachytherapy 2022, 21: 244-254. PMID: 34996715, DOI: 10.1016/j.brachy.2021.11.001.Peer-Reviewed Original Research
2020
Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
Draeger E, Pinkham DW, Chen ZJ, Tien CJ. Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy. Brachytherapy 2020, 20: 401-409. PMID: 33288488, DOI: 10.1016/j.brachy.2020.09.019.Peer-Reviewed Original ResearchFeasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application
Tien CJ, Pinkham DW, Chen ZJ. Feasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application. Brachytherapy 2020, 19: 532-543. PMID: 32327342, DOI: 10.1016/j.brachy.2020.03.002.Peer-Reviewed Original Research
2019
Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy
Tien CJ, Chen ZJ. Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy. Brachytherapy 2019, 18: 883-889. PMID: 31444132, DOI: 10.1016/j.brachy.2019.07.006.Peer-Reviewed Original Research
2017
Comparison of 2D and 3D modeled tumor motion estimation/prediction for dynamic tumor tracking during arc radiotherapy
Liu W, Ma X, Yan H, Chen Z, Nath R, Li H. Comparison of 2D and 3D modeled tumor motion estimation/prediction for dynamic tumor tracking during arc radiotherapy. Physics In Medicine And Biology 2017, 62: n168-n179. PMID: 28263949, DOI: 10.1088/1361-6560/aa64c8.Peer-Reviewed Original ResearchConceptsSystem latencyMotion trackingReal-time imaging techniqueMotion compensation frameworkTracking accuracyBeam directionRespiratory motion dataEstimation/predictionPotential dosimetric advantagesAdditional kVTumor trackingDepth directionTracking latencyView planeDosimetric advantagesMotion dataTracking errorDynamic tumor trackingImaging techniquesBlockage problemDetection errorBlockage issueUnresolved motionTrackingCompensation framework
2011
An integrated approach to segmentation and nonrigid registration for application in image-guided pelvic radiotherapy
Lu C, Chelikani S, Papademetris X, Knisely JP, Milosevic MF, Chen Z, Jaffray DA, Staib LH, Duncan JS. An integrated approach to segmentation and nonrigid registration for application in image-guided pelvic radiotherapy. Medical Image Analysis 2011, 15: 772-785. PMID: 21646038, PMCID: PMC3164526, DOI: 10.1016/j.media.2011.05.010.Peer-Reviewed Original ResearchAlgorithmsBayes TheoremFemaleHumansImaging, Three-DimensionalMaleProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSystems IntegrationTomography, X-Ray ComputedUterine Cervical Neoplasms
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxiaResponse to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. Response to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]. Medical Physics 2010, 37: 1933-1933. PMID: 20443515, DOI: 10.1118/1.3358143.Peer-Reviewed Original ResearchIntegrated Segmentation and Nonrigid Registration for Application in Prostate Image-Guided Radiotherapy
Lu C, Chelikani S, Chen Z, Papademetris X, Staib LH, Duncan JS. Integrated Segmentation and Nonrigid Registration for Application in Prostate Image-Guided Radiotherapy. Lecture Notes In Computer Science 2010, 13: 53-60. PMID: 20879214, DOI: 10.1007/978-3-642-15705-9_7.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsHumansImaging, Three-DimensionalMaleProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSystems IntegrationTomography, X-Ray ComputedConceptsManual segmentationAutomatic segmentationImportant treatment parametersNonrigid registrationImage-guided radiotherapy systemReal patient dataNon-rigid registrationIntegrated SegmentationRegistration partRadiotherapy linear acceleratorSegmentationTreatment imagesImage qualityCone-beam CTTreatment parametersImagesPromising resultsPatient dataKey anatomical structuresLinear acceleratorRegistrationPrevious workRadiotherapy system
2009
AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137. Medical Physics 2009, 36: 5310-5322. PMID: 19994539, PMCID: PMC2776817, DOI: 10.1118/1.3246613.Peer-Reviewed Original ResearchConceptsBiological equivalent doseTumor volumeDose prescriptionStandard of careProstate cancer patientsPermanent interstitial brachytherapyAcute single dosesEffects of edemaCancer patientsSurgical traumaIntraoperative implantationSingle dosesClinical trialsProstate cancerRadiobiological modelsCurrent recommendationsInterstitial brachytherapyMore specific guidelinesRoutine patient treatmentsDifferent dose distributionsTreatment planPatient treatmentTarget volumeMost implantsDose distributionTime dependence of energy spectra of brachytherapy sources and its impact on the half and the tenth value layers
Yue NJ, Chen Z, Hearn RA, Rodgers JJ, Nath R. Time dependence of energy spectra of brachytherapy sources and its impact on the half and the tenth value layers. Medical Physics 2009, 36: 5175-5182. PMID: 19994527, DOI: 10.1118/1.3246843.Peer-Reviewed Original Research2D‐3D registration for prostate radiation therapy based on a statistical model of transmission images
Munbodh R, Tagare HD, Chen Z, Jaffray DA, Moseley DJ, Knisely JP, Duncan JS. 2D‐3D registration for prostate radiation therapy based on a statistical model of transmission images. Medical Physics 2009, 36: 4555-4568. PMID: 19928087, DOI: 10.1118/1.3213531.Peer-Reviewed Original ResearchAlgorithmsData Interpretation, StatisticalHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalInformation Storage and RetrievalMalePattern Recognition, AutomatedPhantoms, ImagingProstatic NeoplasmsRadiographic Image EnhancementRadiotherapy, ConformalReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueConstrained non-rigid registration for use in image-guided adaptive radiotherapy
Greene WH, Chelikani S, Purushothaman K, Knisely JP, Chen Z, Papademetris X, Staib LH, Duncan JS. Constrained non-rigid registration for use in image-guided adaptive radiotherapy. Medical Image Analysis 2009, 13: 809-817. PMID: 19682945, PMCID: PMC2771756, DOI: 10.1016/j.media.2009.07.004.Peer-Reviewed Original ResearchAlgorithmsArtificial IntelligenceHumansMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedRadiotherapy, ConformalReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray Computed
2008
Automated 2D–3D registration of portal images and CT data using line‐segment enhancement
Munbodh R, Chen Z, Jaffray DA, Moseley DJ, Knisely JP, Duncan JS. Automated 2D–3D registration of portal images and CT data using line‐segment enhancement. Medical Physics 2008, 35: 4352-4361. PMID: 18975681, PMCID: PMC3910153, DOI: 10.1118/1.2975143.Peer-Reviewed Original ResearchAlgorithmsArtificial IntelligenceHumansImaging, Three-DimensionalMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray ComputedEvaluation of an electron Monte Carlo dose calculation algorithm for electron beams
Hu YA, Song H, Chen Z, Zhou S, Yin F. Evaluation of an electron Monte Carlo dose calculation algorithm for electron beams. Journal Of Applied Clinical Medical Physics 2008, 9: 1-15. PMID: 18716583, PMCID: PMC5722292, DOI: 10.1120/jacmp.v9i3.2720.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsElectronsMonte Carlo MethodParticle AcceleratorsRadiotherapy Planning, Computer-AssistedConceptsElectron Monte Carlo dose calculation algorithmMonte Carlo dose calculation algorithmGrid sizeDose calculation algorithmCalculation grid sizeCalculation algorithmEMC algorithmElectron beamMonte Carlo simulationsElectron beam directionMeasurement dataCutout factorsCalculation iterationsCarlo simulationsDose distributionMeV electron beamLinac headBeam characteristicsBeam dataBeam directionMinimal measurementsMaximum discrepancyAlgorithmDose calculationsBeamA Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy
Greene W, Chelikani S, Purushothaman K, Chen Z, Knisely J, Staib L, Papademetris X, Duncan J. A Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy. Lecture Notes In Computer Science 2008, 11: 780-788. PMID: 18979817, PMCID: PMC2790815, DOI: 10.1007/978-3-540-85988-8_93.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtificial IntelligenceHumansImaging, Three-DimensionalMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray ComputedConceptsTreatment planProstate image-guided radiotherapyOriginal treatment planRadiation dosageImage-guided radiotherapyTreatment daysRadiotherapy treatment plansCritical organsDifferent patientsPatient dataDifferent treatment daysBladderRectumProstateFemurBone motionCT imagesDosageReal patient dataPatientsRadiotherapy
2007
On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplantsPhoton spectrometry for the determination of the dose‐rate constant of low‐energy photon‐emitting brachytherapy sources
Chen ZJ, Nath R. Photon spectrometry for the determination of the dose‐rate constant of low‐energy photon‐emitting brachytherapy sources. Medical Physics 2007, 34: 1412-1430. PMID: 17500473, DOI: 10.1118/1.2713217.Peer-Reviewed Original ResearchConceptsPhoton spectrometry techniquePhoton spectrometryHigh-resolution gamma-ray spectrometerDosimetry techniquesLow-energy photonsPhoton energy spectrumMono-energetic photonsGamma-ray spectrometerLow-energy photon-emitting brachytherapy sourcesBrachytherapy sourcesLow-energy sourcesAbsolute dosimeterPhoton characteristicsEnergy dependenceDetector sensitivityDetector sizeSolid phantomDose rate measurementsPhotonsDosimetric propertiesRadiation dosimetryDose rate constantDose rateSpectrometry techniquesAccurate measurement
2006
A gradient feature weighted Minimax algorithm for registration of multiple portal images to 3DCT volumes in prostate radiotherapy
Chelikani S, Purushothaman K, Knisely J, Chen Z, Nath R, Bansal R, Duncan J. A gradient feature weighted Minimax algorithm for registration of multiple portal images to 3DCT volumes in prostate radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2006, 65: 535-547. PMID: 16690436, PMCID: PMC2791048, DOI: 10.1016/j.ijrobp.2005.12.032.Peer-Reviewed Original ResearchAutomated 2D‐3D registration of a radiograph and a cone beam CT using line‐segment enhancementa)
Munbodh R, Jaffray DA, Moseley DJ, Chen Z, Knisely JP, Cathier P, Duncan JS. Automated 2D‐3D registration of a radiograph and a cone beam CT using line‐segment enhancementa). Medical Physics 2006, 33: 1398-1411. PMID: 16752576, PMCID: PMC2796183, DOI: 10.1118/1.2192621.Peer-Reviewed Original Research