2019
High-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay
Tien CJ, Carlson DJ, Nath R, Chen ZJ. High-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay. Brachytherapy 2019, 18: 701-710. PMID: 31109870, DOI: 10.1016/j.brachy.2019.04.005.Peer-Reviewed Original Research
2013
Acute toxicity and risk of infection during total skin electron beam therapy for mycosis fungoides
Lloyd S, Chen Z, Foss FM, Girardi M, Wilson LD. Acute toxicity and risk of infection during total skin electron beam therapy for mycosis fungoides. Journal Of The American Academy Of Dermatology 2013, 69: 537-543. PMID: 23849563, DOI: 10.1016/j.jaad.2013.04.063.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAge FactorsAgedAnalysis of VarianceCohort StudiesDermatomycosesDose Fractionation, RadiationDose-Response Relationship, RadiationElectronsFemaleHumansIncidenceMaleMiddle AgedMultivariate AnalysisMycosis FungoidesNeoplasm InvasivenessNeoplasm StagingPrognosisRadiodermatitisRadiotherapy DosageRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsSkin Diseases, BacterialSkin NeoplasmsWhole-Body IrradiationConceptsTotal skin electron beam therapyMycosis fungoidesSkin infectionsElectron beam therapyAcute toxicityBeam therapyAcute treatment toxicityRetrospective study designIncidence of infectionRisk of infectionCommon toxicitiesTreatment toxicityCutaneous infectionsSkin painBaseline incidenceToxicity gradeGrade 3Modern seriesGrade 2Grade 1Consecutive coursesFungoidesInfectionStudy designGrade 4
2011
Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Yu JB, Roberts KB, Peschel RE, Nath R. Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e39-e47. PMID: 21489702, DOI: 10.1016/j.ijrobp.2011.01.071.Peer-Reviewed Original ResearchConceptsImage-guided radiotherapyTesticular dosesFull-fan modeProstate cancerFemoral headLess doseCBCT scansHalf-fan modeProstate cancer patientsKilovoltage cone-beamCancer patientsIntensity-modulated radiotherapy (IMRT) treatmentKilovoltage CBCTSuperior-inferior directionCone beamDosesCBCT fieldProstate patientsRectumDoseProstateMore doseRadiotherapy treatmentPatientsRadiotherapy
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxia
2005
Dose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures
Nath R, Bongiorni P, Chen Z, Gragnano J, Rockwell S. Dose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures. International Journal Of Radiation Biology 2005, 81: 689-699. PMID: 16368647, DOI: 10.1080/09553000500401551.Peer-Reviewed Original ResearchConceptsContinuous low dose rate irradiationDose rate irradiationLow dose rate irradiationRate irradiationInterstitial brachytherapyHigh dose rate irradiationAcute exposureRhabdomyosarcoma cellsPermanent interstitial brachytherapyRelative biological effectivenessBA1112 tumorsSame dose rateSurvival curvesHigh linear energy transferAcute irradiationTumor cellsCell survival curvesBiological effectivenessLow dose rateDose-rate effectDose rateBrachytherapy