Bayesian network-based Mendelian randomization for variant prioritization and phenotypic causal inference
Sun J, Zhou J, Gong Y, Pang C, Ma Y, Zhao J, Yu Z, Zhang Y. Bayesian network-based Mendelian randomization for variant prioritization and phenotypic causal inference. Human Genetics 2024, 143: 1081-1094. PMID: 38381161, DOI: 10.1007/s00439-024-02640-x.Peer-Reviewed Original ResearchMendelian randomizationGenetic instrumental variablesGenomic dataIndividual-level dataInstrumental variablesUK BiobankFalse-positive discoveriesGenetic structureVariant prioritizationEffect estimatesMR methodsGene interactionsGenetic variantsCausal inferencePsychiatric disordersStatistical powerBlood pressureBayesian frameworkInference frameworkInferenceBiobankEstimationCausal relationshipsPleiotropyGenes