High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome
Delgado E, Boisen M, Laskey R, Chen R, Song C, Sallit J, Yochum Z, Andersen C, Sikora M, Wagner J, Safe S, Elishaev E, Lee A, Edwards R, Haluska P, Tseng G, Schurdak M, Oesterreich S. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecologic Oncology 2016, 141: 348-356. PMID: 26946093, PMCID: PMC5154956, DOI: 10.1016/j.ygyno.2016.02.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Ovarian EpithelialCell Line, TumorFemaleGenomeHeterograftsHumansImmunohistochemistryMiceMice, SCIDNeoplasms, Glandular and EpithelialNuclear Receptor Subfamily 4, Group A, Member 1Ovarian NeoplasmsPrognosisRNA, MessengerConceptsHigh-grade serous ovarian cancerWorse progression-free survivalProgression-free survivalOvarian cancer cell linesCancer cell linesFree survivalNuclear receptorsOvarian cancerOvarian cancer tissue samplesCell linesGrade serous ovarian cancerExpression of NR4A1Ovarian cancer pathogenesisStage of diseaseTCGA dataNormal ovarian tissuesSerous ovarian cancerCancer tissue samplesNormal ovarian samplesRelevant nuclear receptorsHGSOC cell linesCritical nuclear receptorOverexpression of NR4A1Orphan nuclear receptor NR4A1Ovarian tumors