TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression
Godse N, Khan N, Yochum Z, Gomez-Casal R, Kemp C, Shiwarski D, Seethala R, Kulich S, Seshadri M, Burns T, Duvvuri U. TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression. Clinical Cancer Research 2017, 23: 7324-7332. PMID: 28899969, PMCID: PMC5898434, DOI: 10.1158/1078-0432.ccr-17-1561.Peer-Reviewed Original ResearchConceptsNeck squamous cell carcinomaGreater tumor sizeSquamous cell carcinomaCalcium-activated chloride channelClin Cancer ResERK 1/2 activityVariety of cancersTMEM16A overexpressionCisplatin-resistant phenotypeAggressive diseaseTumor sizeCell carcinomaHuman HNSCCLaryngeal cancerHNSCC samplesTMEM16A expressionChemoradiation failureAnti-apoptotic roleOverexpression rateTranslational investigationsMalignant cellsPotential biomarkersSimilar outcomesCancer ResProtein expression