The HGF-MET signaling pathway is enriched in LUAC brain metastases.
Velez M, Yochum Z, Chandran U, Chakka A, Bhattacharya S, Somasundaram A, LaFramboise W, Wallweber G, Ravanera R, Kurland B, Dacic S, Stabile L, Burns T. The HGF-MET signaling pathway is enriched in LUAC brain metastases. Journal Of Clinical Oncology 2019, 37: e20597-e20597. DOI: 10.1200/jco.2019.37.15_suppl.e20597.Peer-Reviewed Original ResearchBrain metastasesHepatocyte growth factorEpithelial-mesenchymal transitionMET amplificationEMT markersNon-small cell lung cancer patientsLung adenocarcinoma brain metastasisMET activationCell lung cancer patientsLung cancer patientsPaired samplesSubset of casesMET alterationsMET-TKIPoor prognosisCancer patientsPrimary tumorMET inhibitorsEMT transcription factorsMET expressionMetastasisPrimary siteMolecular alterationsPathogenic variantsC-Met