2024
Childhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 1-14. PMID: 38762606, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass indexGreater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample. Biological Psychiatry 2024, 95: s41. DOI: 10.1016/j.biopsych.2024.02.104.Peer-Reviewed Original Research353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity
Harvanek Z, Zhang X, Xu K, Sinha R. 353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity. Biological Psychiatry 2024, 95: s244. DOI: 10.1016/j.biopsych.2024.02.852.Peer-Reviewed Original Research
2023
Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample. Neurobiology Of Stress 2023, 26: 100557. PMID: 37501940, PMCID: PMC10369475, DOI: 10.1016/j.ynstr.2023.100557.Peer-Reviewed Original ResearchTraumatic eventsGrimAge accelerationMore traumatic eventsWhite participantsExploratory mediation analysisMajor life eventsImpact of stressAssaultive traumaPsychological dataCross-sectional sampleCommunity sampleLife eventsMediation analysisLifetime stressRace-related differencesChronic stressorsCumulative stressorsYoung adultsCumulative stressChronic illnessYoung adult populationStressorsGreater stressHealthy adultsParticipantsThe Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health
Harvanek Z, Boks M, Vinkers C, Higgins-Chen A. The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health. Biological Psychiatry 2023, 94: 694-705. PMID: 36764569, PMCID: PMC10409884, DOI: 10.1016/j.biopsych.2023.02.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
P75. Stress and Trauma Mediate Some, But Not All, Differences in GrimAge Acceleration Between Black and White Participants in Observed Cohort Study
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. P75. Stress and Trauma Mediate Some, But Not All, Differences in GrimAge Acceleration Between Black and White Participants in Observed Cohort Study. Biological Psychiatry 2022, 91: s117. DOI: 10.1016/j.biopsych.2022.02.309.Peer-Reviewed Original Research
2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Harvanek ZM, Fogelman N, Xu K, Sinha R. Psychological and biological resilience modulates the effects of stress on epigenetic aging. Translational Psychiatry 2021, 11: 601. PMID: 34839356, PMCID: PMC8627511, DOI: 10.1038/s41398-021-01735-7.Peer-Reviewed Original ResearchConceptsEmotion regulationResilience factorsCumulative stressWorse emotion regulationPoor emotion regulationPsychological resilience factorsNegative long-term health consequencesCommunity sampleEffects of stressBiological age accelerationPhysical outcomesMore stressBehavioral factorsChronic stressGrimAge accelerationHealth consequencesStress physiologyLong-term health consequencesEpigenetic agingPhysiologic measuresHealthy populationFinal modelAge accelerationAgingRelationship
2019
Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception
Gendron CM, Chakraborty TS, Chung BY, Harvanek ZM, Holme KJ, Johnson JC, Lyu Y, Munneke AS, Pletcher SD. Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception. Annual Review Of Physiology 2019, 82: 1-23. PMID: 31635526, PMCID: PMC7012701, DOI: 10.1146/annurev-physiol-021119-034440.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSensory perceptionDecision-making behaviorTime perceptionLine of researchSocial perceptionNeural mechanismsSensory cuesFood perceptionThreat perceptionPerceptive experienceNeuronal mechanismsAge-related diseasesPerceptionNovel therapeutic targetAge-related physiologyTherapeutic targetGroups of neuronsInput influencesCuesPhysiologySensory neuronsAgingOrganismalGeneral thoughtsHuman healthA Structured Approach to Introducing Residents to Group Therapy Leadership
Harvanek ZM, Millard H. A Structured Approach to Introducing Residents to Group Therapy Leadership. Academic Psychiatry 2019, 43: 652-653. PMID: 31485999, DOI: 10.1007/s40596-019-01112-z.Peer-Reviewed Educational Materials
2017
Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?
Henderson D, Huebner C, Markowitz M, Taube N, Harvanek ZM, Jakob U, Knoefler D. Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin? Redox Biology 2017, 14: 386-390. PMID: 29055282, PMCID: PMC5647470, DOI: 10.1016/j.redox.2017.10.003.Peer-Reviewed Original ResearchConceptsC. elegansC. elegans larvaeRedox stateVivo redox stateReduced redox statePoikilothermic organismsDevelopmental temperatureLifespan extensionRedox statusMechanistic underpinningsBeneficial long-term consequencesElegansExpression levelsOrganismsVivo redox statusWormsRedox levelsCaenorhabditisLifespanPeroxiredoxinsGrowth temperatureLarvaeAnimalsUpregulationEffect of temperaturePerceptive costs of reproduction drive ageing and physiology in male Drosophila
Harvanek ZM, Lyu Y, Gendron CM, Johnson JC, Kondo S, Promislow DEL, Pletcher SD. Perceptive costs of reproduction drive ageing and physiology in male Drosophila. Nature Ecology & Evolution 2017, 1: 0152. PMID: 28812624, PMCID: PMC5657004, DOI: 10.1038/s41559-017-0152.Peer-Reviewed Original ResearchLife-history traitsReproductive costsBenefits of matingPopulation genetic studiesCost of reproductionAct of matingMale Drosophila melanogasterOrganismal fitnessDrosophila melanogasterReproductive effortMale DrosophilaNatural selectionStress resistancePheromone perceptionPhysiological constraintsGenetic studiesMechanistic basisKey survivalPhysiological costsReproductionFat storageMolecular frameworkMatingTraitsImportant insights
2016
A computational approach to studying ageing at the individual level
Harvanek ZM, Mourão MA, Schnell S, Pletcher SD. A computational approach to studying ageing at the individual level. Proceedings Of The Royal Society B 2016, 283: 20152346. PMID: 26865300, PMCID: PMC4760160, DOI: 10.1098/rspb.2015.2346.Peer-Reviewed Original Research
2014
FLIC: High-Throughput, Continuous Analysis of Feeding Behaviors in Drosophila
Ro J, Harvanek ZM, Pletcher SD. FLIC: High-Throughput, Continuous Analysis of Feeding Behaviors in Drosophila. PLOS ONE 2014, 9: e101107. PMID: 24978054, PMCID: PMC4076220, DOI: 10.1371/journal.pone.0101107.Peer-Reviewed Original ResearchWater sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling
Waterson MJ, Chung BY, Harvanek ZM, Ostojic I, Alcedo J, Pletcher SD. Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 8137-8142. PMID: 24821805, PMCID: PMC4050545, DOI: 10.1073/pnas.1315461111.Peer-Reviewed Original ResearchConceptsMetabolic homeostasisAdipokinetic hormone signalingDrosophila lifespanHormone signalingAKH receptorMutant effectsMetabolic shiftPhysiological homeostasisHealthy lifespanMetabolic waterWater availabilityHomeostasisAKHGustatory systemLifespanGustatory signalsInternal lipidsCentral nervous system integrationEndocrine systemTaxaSensory regulationLong-term healthWater storesSignalingPhysiology
2013
Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward
Gendron CM, Kuo TH, Harvanek ZM, Chung BY, Yew JY, Dierick HA, Pletcher SD. Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward. Science 2013, 343: 544-548. PMID: 24292624, PMCID: PMC4042187, DOI: 10.1126/science.1243339.Peer-Reviewed Original ResearchConceptsDrosophila life spanMale fruit fliesRNA sequencing experimentsLife spanDrosophila melanogasterFemale sexual pheromoneGustatory receptorsFruit flyPheromone perceptionSequencing experimentsNeuropeptide FMolecular processesSexual pheromonesPheromone effectsPhysiologyFat storesMelanogasterTaxaSensory perceptionMatingFliesStarvationPheromoneNeuronsReceptors
2011
Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae
Tang W, Dominska M, Greenwell PW, Harvanek Z, Lobachev KS, Kim HM, Narayanan V, Mirkin SM, Petes TD. Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae. PLOS Genetics 2011, 7: e1001270. PMID: 21249181, PMCID: PMC3020933, DOI: 10.1371/journal.pgen.1001270.Peer-Reviewed Original ResearchConceptsDouble-strand breaksMitotic crossoversNon-reciprocal transferExpansions of trinucleotideFriedreich's ataxiaGenome instabilityMeiotic recombinationUnreplicated chromosomesDNA sequencesRecombination eventsCell cycleSaccharomyces cerevisaeYeastMajor classesChromosomesPotent sourceRepeatsHeterozygosityTrinucleotideCerevisaeRecombinationSequence