2016
Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells
Yasumoto Y, Miyazaki H, Vaidyan LK, Kagawa Y, Ebrahimi M, Yamamoto Y, Ogata M, Katsuyama Y, Sadahiro H, Suzuki M, Owada Y. Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells. PLOS ONE 2016, 11: e0147717. PMID: 26808816, PMCID: PMC4726602, DOI: 10.1371/journal.pone.0147717.Peer-Reviewed Original ResearchConceptsFatty acid synthaseGlioma stem cellsStem cellsCellular lipid metabolismCellular metabolic changesKey lipogenic enzymesPatient-derived glioma stem cellsLipid biosynthesisFatty acid binding proteinAcid binding proteinPharmacological inhibitorsSynthesis assayBinding proteinAcid synthaseCerulenin treatmentGlial fibrillary acidic protein (GFAP) expressionGSC stemnessProtein expressionCancer cellsDe novo lipogenesisLipogenic enzymesImmunocytochemical analysisMarker nestinStemness markersDecrease expression
2013
Pathological features of highly invasive glioma stem cells in a mouse xenograft model
Sadahiro H, Yoshikawa K, Ideguchi M, Kajiwara K, Ishii A, Ikeda E, Owada Y, Yasumoto Y, Suzuki M. Pathological features of highly invasive glioma stem cells in a mouse xenograft model. Brain Tumor Pathology 2013, 31: 77-84. PMID: 23670138, DOI: 10.1007/s10014-013-0149-x.Peer-Reviewed Original ResearchConceptsGlioma stem cellsMouse xenograft modelSubventricular zoneXenograft modelCorpus callosumTumor xenograft modelMatrigel invasion assaysGSC linesInvasive potentialHigh invasive potentialStem cellsPathological featuresMultimodal therapyContralateral hemisphereTumor bulkMouse brainTumor progressionHuman glioblastomaMigratory propertiesMigration abilityCallosumCells