2023
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability
An S, Mohanty J, Tome F, Suzuki Y, Lax I, Schlessinger J. Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2219128120. PMID: 36745784, PMCID: PMC9962926, DOI: 10.1073/pnas.2219128120.Peer-Reviewed Original ResearchConceptsHeparan sulfate proteoglycanCellular stabilityCell membraneSingle-molecule fluorescenceProtein kinase responsesChinese hamster ovary cellsFGF moleculesHamster ovary cellsFactor bindsReceptor assemblyReceptor dimerizationGrowth factor bindsHigh-affinity bindingFGF1 stimulationKinase responseCHO cellsOvary cellsSulfate proteoglycanIntracellular CaKlotho proteinFGFR1cPotential roleRegulationΒKlothoCells
2006
Receptor Protein Tyrosine Phosphatase γ Is a Marker for Pyramidal Cells and Sensory Neurons in the Nervous System and Is Not Necessary for Normal Development
Lamprianou S, Vacaresse N, Suzuki Y, Meziane H, Buxbaum JD, Schlessinger J, Harroch S. Receptor Protein Tyrosine Phosphatase γ Is a Marker for Pyramidal Cells and Sensory Neurons in the Nervous System and Is Not Necessary for Normal Development. Molecular And Cellular Biology 2006, 26: 5106-5119. PMID: 16782895, PMCID: PMC1489161, DOI: 10.1128/mcb.00101-06.Peer-Reviewed Original ResearchConceptsReceptor protein tyrosine phosphatase gammaProtein tyrosine phosphatase gammaPotential biological functionsObvious phenotypeBeta-galactosidase geneRPTPgammaVariety of tissuesBiological functionsMouse embryosBiological roleSensory neuronsLack of expressionNormal developmentSensory organsCortical layers IIExpressionGlial cellsPyramidal neuronsAdult brainStratum pyramidalePyramidal cellsLow expressionPotential rolePrimary culturesLayers II