2022
Sex-based differences in atrial fibrillation ablation adverse events
Mszar R, Friedman D, Ong E, Du C, Wang Y, Zeitler E, Cunningham S, Akar J, Curtis J, Freeman J. Sex-based differences in atrial fibrillation ablation adverse events. Heart 2022, 109: 595-605. PMID: 36104219, DOI: 10.1136/heartjnl-2022-321192.Peer-Reviewed Original ResearchConceptsAcute pulmonary vein isolationAdverse eventsPulmonary vein isolationAtrial fibrillationHigh riskSex-based differencesVein isolationCatheter ablationFemale sexLarge prospective registryHospital adverse eventsMajor adverse eventsObservational cohort studyPhrenic nerve damageAF ablation proceduresQuality of lifeAblation RegistryMore comorbiditiesProspective registryAF ablationCohort studyPericardial effusionNerve damagePatient sexVascular injury
2012
Impact of Community Wealth on Use of Cardiac-Resynchronization Therapy With Defibrillators for Heart Failure Patients
Farmer S, Tuohy E, Small D, Wang Y, Groeneveld P. Impact of Community Wealth on Use of Cardiac-Resynchronization Therapy With Defibrillators for Heart Failure Patients. Circulation Cardiovascular Quality And Outcomes 2012, 5: 798-807. PMID: 23093561, DOI: 10.1161/circoutcomes.112.965509.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesChi-Square DistributionCommunity Health ServicesDefibrillators, ImplantableEconomics, HospitalElectric CountershockFemaleHealth Care CostsHealth Services AccessibilityHealthcare DisparitiesHeart FailureHumansIncomeLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioRegistriesResidence CharacteristicsRetrospective StudiesTreatment OutcomeUnited StatesConceptsCardiac resynchronization therapyHospital resourcesNational Cardiovascular Data RegistryHeart failure patientsHeart failure therapyPatient-level variablesMajor health policy concernFailure patientsFailure therapyInsurance statusHospital characteristicsPatient stayCardiovascular disease treatmentHealth policy concernData registryPatientsPatient volumeMedian household incomeHealth policyTherapyInsurance coverageSignificant predictorsDisease treatmentHospital ownershipAverage median household income
2011
Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention
Curtis JP, Rathore SS, Wang Y, Chen J, Nallamothu BK, Krumholz HM. Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2011, 5: 21-30. PMID: 22147887, PMCID: PMC3801197, DOI: 10.1161/circoutcomes.110.960385.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionHospital quartilesHospital mortalityIABP useCoronary interventionBalloon pumpHospital characteristicsST-segment elevation myocardial infarctionDepressed left ventricular functionHigh-risk PCI patientsSegment elevation myocardial infarctionElevation myocardial infarctionLeft ventricular functionHierarchical logistic regression modelsLogistic regression modelsIABP usageCardiogenic shockPCI patientsCathPCI RegistryHemodynamic supportVentricular functionHospital variationMultivariable analysisPhysician Procedure Volume and Complications of Cardioverter-Defibrillator Implantation
Freeman JV, Wang Y, Curtis JP, Heidenreich PA, Hlatky MA. Physician Procedure Volume and Complications of Cardioverter-Defibrillator Implantation. Circulation 2011, 125: 57-64. PMID: 22095828, DOI: 10.1161/circulationaha.111.046995.Peer-Reviewed Original ResearchConceptsPhysician procedure volumeProcedure volumeHospital mortalityICD implantationHospital characteristicsPhysician specialtyNational Cardiovascular Data Registry ICD RegistryImplantable cardioverter-defibrillator placementInitial ICD implantationRate of complicationsCardioverter-defibrillator implantationHospital procedure volumeClustering of patientsAnnual procedure volumeOutcomes of proceduresVolume of proceduresHierarchical logistic regressionHospital complicationsComplication rateHospital volumePatient characteristicsProcedural complicationsHighest quartileInverse relationshipComplicationsInfluence of Age on Perioperative Complications Among Patients Undergoing Implantable Cardioverter-Defibrillators for Primary Prevention in the United States
Tsai V, Goldstein MK, Hsia HH, Wang Y, Curtis J, Heidenreich PA. Influence of Age on Perioperative Complications Among Patients Undergoing Implantable Cardioverter-Defibrillators for Primary Prevention in the United States. Circulation Cardiovascular Quality And Outcomes 2011, 4: 549-556. PMID: 21878667, DOI: 10.1161/circoutcomes.110.959205.Peer-Reviewed Original ResearchConceptsAdverse eventsICD RegistryPrimary prevention ICD recipientsEnd pointImplantable cardioverter defibrillator recipientsPatients 85 yearsPrimary prevention patientsMinor adverse eventsPrimary end pointSecondary end pointsMajor adverse eventsCongestive heart failureCoronary artery diseaseLength of stayInfluence of ageHospital mortalityICD trialsPerioperative complicationsPeriprocedural complicationsArtery diseaseHeart failureICD recipientsRenal diseaseIncreased oddsAtrial fibrillationAge Differences in Primary Prevention Implantable Cardioverter‐Defibrillator Use in U.S. Individuals
Tsai V, Goldstein MK, Hsia HH, Wang Y, Curtis J, Heidenreich PA, Registry O. Age Differences in Primary Prevention Implantable Cardioverter‐Defibrillator Use in U.S. Individuals. Journal Of The American Geriatrics Society 2011, 59: 1589-1595. PMID: 21883101, DOI: 10.1111/j.1532-5415.2011.03542.x.Peer-Reviewed Original ResearchConceptsICD RegistryICD useNonarrhythmic deathHigh riskImplantable cardioverter-defibrillator (ICD) useHigh comorbid burdenPrior myocardial infarctionRisk of deathHigh-risk individualsRisk stratification systemOlder U.S. adultsYounger age groupsComorbid burdenICD implantationEjection fractionICD recipientsPrimary preventionRetrospective studyMyocardial infarctionMortality riskLower riskAge groupsU.S. adultsYounger groupOlder adultsDual-Chamber Implantable Cardioverter-Defibrillator Selection Is Associated With Increased Complication Rates and Mortality Among Patients Enrolled in the NCDR Implantable Cardioverter-Defibrillator Registry
Dewland TA, Pellegrini CN, Wang Y, Marcus GM, Keung E, Varosy PD. Dual-Chamber Implantable Cardioverter-Defibrillator Selection Is Associated With Increased Complication Rates and Mortality Among Patients Enrolled in the NCDR Implantable Cardioverter-Defibrillator Registry. Journal Of The American College Of Cardiology 2011, 58: 1007-1013. PMID: 21867834, DOI: 10.1016/j.jacc.2011.04.039.Peer-Reviewed Original ResearchConceptsDual-chamber ICDHospital mortalityComplication rateDevice implantationDual-chamber implantable cardioverter-defibrillator (ICD) implantationNational Cardiovascular Data Registry ICD RegistryImplantable Cardioverter-Defibrillator RegistrySingle-chamber ICD implantationImplantable cardioverter defibrillator implantationHospital complication ratesSingle-chamber defibrillatorsCardioverter-defibrillator implantationMajority of patientsReal-world populationDual-chamber devicesSingle-chamber devicesLongitudinal cohort designMedical comorbiditiesPeriprocedural complicationsAdverse eventsBaseline characteristicsICD implantationICD indicationICD RegistryICD useImplantable Cardioverter-Defibrillator Registry Risk Score Models for Acute Procedural Complications or Death After Implantable Cardioverter-Defibrillator Implantation
Haines DE, Wang Y, Curtis J. Implantable Cardioverter-Defibrillator Registry Risk Score Models for Acute Procedural Complications or Death After Implantable Cardioverter-Defibrillator Implantation. Circulation 2011, 123: 2069-2076. PMID: 21537001, DOI: 10.1161/circulationaha.110.959676.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillator implantationSimple risk scoreCardioverter-defibrillator implantationAdverse eventsRisk scoreLower riskNew York Heart Association class IIILow-risk subsetPrior valve surgeryAcute procedural complicationsChronic lung diseaseRisk stratification schemaAvailable clinical variablesBlood urea nitrogenIntensity of careRisk score modelLogistic regression modelsHospital complicationsAcute complicationsHospital deathValve surgeryICD implantationPostprocedural complicationsICD RegistryProcedural complicationsUse of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study
Dorfman AL, Fazel R, Einstein AJ, Applegate KE, Krumholz HM, Wang Y, Christodoulou E, Chen J, Sanchez R, Nallamothu BK. Use of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study. JAMA Pediatrics 2011, 165: 458-464. PMID: 21199972, PMCID: PMC3686496, DOI: 10.1001/archpediatrics.2010.270.Peer-Reviewed Original ResearchConceptsDiagnostic imaging proceduresTomographic scanImaging proceduresRetrospective cohort analysisPopulation-based ratesPediatric populationPlain radiographyCohort analysisHigh dosesMedical diagnostic imaging proceduresStudy periodAppropriate useChildrenHigh rateMedical imaging proceduresScansFrequent useHealth care marketUS health care marketYearsPatientsInfantsPopulationCare marketUnitedHealthcare
2010
Regional Variation in the Use of Implantable Cardioverter-Defibrillators for Primary Prevention
Matlock DD, Peterson PN, Heidenreich PA, Lucas FL, Malenka DJ, Wang Y, Curtis JP, Kutner JS, Fisher ES, Masoudi FA. Regional Variation in the Use of Implantable Cardioverter-Defibrillators for Primary Prevention. Circulation Cardiovascular Quality And Outcomes 2010, 4: 114-121. PMID: 21139094, DOI: 10.1161/circoutcomes.110.958264.Peer-Reviewed Original ResearchConceptsPrimary prevention ICDsProportion of patientsTrial inclusion criteriaInclusion criteriaPrimary preventionTrial criteriaPhysician supplyNational Cardiovascular Data RegistryImplantable cardioverter defibrillatorHospital referral regionsRace-adjusted ratesCross-sectional analysisICD implantationICD placementCardioverter defibrillatorReferral regionsData registryPotential overusePatientsICDDeath variesRate ratioService populationGeographic variationRegional variationThe relationship between systolic blood pressure on admission and mortality in older patients with heart failure
Vidán MT, Bueno H, Wang Y, Schreiner G, Ross JS, Chen J, Krumholz HM. The relationship between systolic blood pressure on admission and mortality in older patients with heart failure. European Journal Of Heart Failure 2010, 12: 148-155. PMID: 20083624, PMCID: PMC2807767, DOI: 10.1093/eurjhf/hfp195.Peer-Reviewed Original ResearchConceptsAdmission systolic blood pressureSystolic blood pressureHeart failureBlood pressureOlder patientsNational Heart Failure ProjectHigher systolic blood pressureInitial systolic blood pressureHeart Failure ProjectMultivariable logistic regressionPrevious hypertensionSBP 90Ventricular dysfunctionClinical factorsIndependent associationOdds ratioMedicare patientsMortality ratePatientsMmHgLogistic regressionMortalityAdmissionSubgroupsInverse relationship
2008
Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure
McNamara R, Austin B, Wang Y, Smith G, Vaccarine V, Krumholz H. Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure. Clinical Cardiology 2008, 31: 119-124. PMID: 18383045, PMCID: PMC6653267, DOI: 10.1002/clc.20118.Peer-Reviewed Original ResearchConceptsQuality of lifeEjection fractionHeart failureLong-term survivorsFunctional declineSystolic functionKansas City Cardiomyopathy Questionnaire scoreModest survival advantageReduced ejection fractionDaily living scoreDisease-related qualityPredictors of mortalityHeart failure patientsClinical summary scoreLong-term survivalHigh mortality rateKCCQ scoresRenal insufficiencyFailure patientsLiving scoreDiabetes mellitusOverall mortalityPrimary outcomeLimitation scoresQOL scores
2001
The association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project
Barron H, Harr S, Radford M, Wang Y, Krumholz H. The association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project. Journal Of The American College Of Cardiology 2001, 38: 1654-1661. PMID: 11704377, DOI: 10.1016/s0735-1097(01)01613-8.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionWhite blood cell countBlood cell countWBC countWhite blood cellsYears of ageIndependent predictorsCell countDevelopment of AMIAcute myocardial infarction mortalityHospital clinical eventsLong-term mortalityRisk-stratify patientsCoronary artery diseaseCooperative Cardiovascular Project databaseStrong independent predictorCooperative Cardiovascular ProjectMyocardial infarction mortalityImportant clinical implicationsHospital mortalityArtery diseaseHospital eventsClinical eventsHighest quintileLowest quintileBlood Transfusion in Elderly Patients with Acute Myocardial Infarction
Wu W, Rathore S, Wang Y, Radford M, Krumholz H. Blood Transfusion in Elderly Patients with Acute Myocardial Infarction. New England Journal Of Medicine 2001, 345: 1230-1236. PMID: 11680442, DOI: 10.1056/nejmoa010615.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionBlood transfusionMyocardial infarctionElderly patientsHematocrit valuesMortality rateLower short-term mortality rateMedicare beneficiaries 65 yearsShort-term mortality rateUse of transfusionsCoronary artery diseaseBeneficiaries 65 yearsDegree of anemiaLow hematocrit valuesArtery diseaseRetrospective studySubgroup analysisTransfusionPatientsAdmissionInfarctionMortalityHematocritAdverse effectsAnemiaAcute myocardial infarction in the elderly: differences by age
Mehta R, Rathore S, Radford M, Wang Y, Wang Y, Krumholz H. Acute myocardial infarction in the elderly: differences by age. Journal Of The American College Of Cardiology 2001, 38: 736-741. PMID: 11527626, DOI: 10.1016/s0735-1097(01)01432-2.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAge-associated differencesElderly patientsClinical characteristicsAge groupsMyocardial infarctionThirty-day mortality rateMedicare beneficiaries ageOne-year mortalityPrior coronary diseaseProportion of patientsST-segment elevationOlder age groupsSignificant age-associated differencesChest painEffect of ageOlder patientsRenal insufficiencyCoronary diseaseHeart failureHospital admissionPatient characteristicsSuccessive age groupsSymptom onsetDiabetic patientsQuality of care among elderly patients hospitalized with unstable angina
Shahi C, Rathore S, Wang Y, Thakur R, Wu W, Lewis J, Petrillo M, Radford M, Krumholz H. Quality of care among elderly patients hospitalized with unstable angina. American Heart Journal 2001, 142: 263-270. PMID: 11479465, DOI: 10.1067/mhj.2001.116477.Peer-Reviewed Original ResearchConceptsQuality of careMinutes of admissionUnstable anginaHealth care policyElderly patientsTherapeutic anticoagulationIntravenous heparinElectrocardiographic examinationCare policyPrescription of aspirinUse of aspirinHalf of patientsEligible patientsRisk stratificationConnecticut hospitalsElderly MedicareAnginaPatientsTherapeutic contraindicationsTherapeutic interventionsAspirinAdmissionHospitalCareAnticoagulationPredicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project
Krumholz H, Chen J, Chen Y, Wang Y, Radford M. Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project. Journal Of The American College Of Cardiology 2001, 38: 453-459. PMID: 11499737, DOI: 10.1016/s0735-1097(01)01395-x.Peer-Reviewed Original ResearchConceptsOne-year mortalityAcute myocardial infarctionMyocardial infarctionPeripheral vascular diseaseCohort of patientsBody mass indexCooperative Cardiovascular ProjectRisk of mortalityDeath one yearPopulation-based sampleSimple risk modelRenal dysfunctionVentricular dysfunctionElderly patientsOlder patientsUrinary incontinenceHeart failureMass indexAcute carePrognostic importanceMean ageVascular diseaseMedical recordsRisk groupsOlder survivors
2000
Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures
Mattera J, de Leon C, Wackers F, Williams C, Wang Y, Krumholz H. Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures. American Heart Journal 2000, 140: 409-418. PMID: 10966538, DOI: 10.1067/mhj.2000.108518.Peer-Reviewed Original ResearchConceptsGeneral health perceptionHealth-related qualityPhysical functioningHealth perceptionMyocardial perfusion imagingHealth statusExercise testingPerfusion imagingMedical Outcomes Study Short Form SurveyPatients' health-related qualityShort Form SurveyAssociation of patientGeneral health statusImportant outcome measureSuccess of treatmentConsecutive patientsSF-36Metabolic equivalentsNoninvasive testingExercise testPatient outcomesIndividual patientsOutcome measuresForm SurveyPatient's viewpoint
1999
Comparing AMI Mortality Among Hospitals in Patients 65 Years of Age and Older
Krumholz H, Chen J, Wang Y, Radford M, Chen Y, Marciniak T. Comparing AMI Mortality Among Hospitals in Patients 65 Years of Age and Older. Circulation 1999, 99: 2986-2992. PMID: 10368115, DOI: 10.1161/01.cir.99.23.2986.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionWhite blood cell countPatients 65 yearsSystolic blood pressureCongestive heart failureMedical chart reviewReceiver-operating characteristic curveBlood cell countRisk-adjusted outcomesYears of ageAdministrative billing codesRisk-adjustment modelsHospital outcomesSerum creatinineChart reviewDerivation cohortHeart failurePatient characteristicsBlood pressureCardiac arrestValidation cohortCandidate predictor variablesAMI mortalityBilling codes
1997
Quality of Care for Elderly Patients Hospitalized With Heart Failure
Krumholz HM, Wang Y, Parent EM, Mockalis J, Petrillo M, Radford MJ. Quality of Care for Elderly Patients Hospitalized With Heart Failure. JAMA Internal Medicine 1997, 157: 2242-2247. PMID: 9343001, DOI: 10.1001/archinte.1997.00440400092011.Peer-Reviewed Original ResearchConceptsHeart failureQuality of careEnzyme inhibitorsElderly patientsClinical practiceResearch Clinical Practice GuidelinesLeft ventricular ejection fractionLeft ventricular systolic functionRetrospective medical record reviewAngiotensin-converting enzyme inhibitorSevere aortic stenosisPercentage of patientsVentricular systolic functionMedical record reviewVentricular ejection fractionClinical practice guidelinesPrincipal discharge diagnosisAcute care hospitalsActual clinical practiceHealth care policyChart reviewSystolic functionAortic stenosisAppropriate patientsCare hospital