2011
Genome‐Wide Studies Reveal That Lin28 Enhances the Translation of Genes Important for Growth and Survival of Human Embryonic Stem Cells
Peng S, Chen L, Lei X, Yang L, Lin H, Carmichael GG, Huang Y. Genome‐Wide Studies Reveal That Lin28 Enhances the Translation of Genes Important for Growth and Survival of Human Embryonic Stem Cells. Stem Cells 2011, 29: 496-504. PMID: 21425412, DOI: 10.1002/stem.591.Peer-Reviewed Original ResearchConceptsRNA helicase AHuman embryonic stem cellsEmbryonic stem cellsLin28-dependent stimulationTranslation of genesStem cellsLet-7 microRNADominant negative inhibitorPolysome profilingGenes ImportantRibosomal proteinsCellular mRNAsTarget genesDeep sequencingReporter analysisMetabolic enzymesLin28Cell growthExpression levelsGenesTranslationCellsGrowthImmunoprecipitationMicroRNAs
2001
Splicing Factors SRp20 and 9G8 Promote the Nucleocytoplasmic Export of mRNA
Huang Y, Steitz J. Splicing Factors SRp20 and 9G8 Promote the Nucleocytoplasmic Export of mRNA. Molecular Cell 2001, 7: 899-905. PMID: 11336712, DOI: 10.1016/s1097-2765(01)00233-7.Peer-Reviewed Original ResearchNucleocytoplasmic mRNA Transport
Huang Y, Carmichael G. Nucleocytoplasmic mRNA Transport. Results And Problems In Cell Differentiation 2001, 34: 139-155. PMID: 11288673, DOI: 10.1007/978-3-540-40025-7_9.Peer-Reviewed Original ResearchConceptsMRNA exportMRNA transportMature mRNA moleculesMRNA nuclear exportViral model systemNuclear pore complexRNA polymerase IIMessenger RNA precursorsFundamental biological processesNucleocytoplasmic mRNA transportRemoval of intronsPolymerase IIPore complexNuclear exportRNA precursorsMRNA moleculesBiological processesProcessing reactionsModel systemCytoplasmDetailed mechanismIntronsPolyadenylationSplicingExport
1999
Intronless mRNA transport elements may affect multiple steps of pre‐mRNA processing
Huang Y, Wimler K, Carmichael G. Intronless mRNA transport elements may affect multiple steps of pre‐mRNA processing. The EMBO Journal 1999, 18: 1642-1652. PMID: 10075934, PMCID: PMC1171251, DOI: 10.1093/emboj/18.6.1642.Peer-Reviewed Original Research
1997
The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs
Huang Y, Carmichael G. The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 10104-10109. PMID: 9294170, PMCID: PMC23318, DOI: 10.1073/pnas.94.19.10104.Peer-Reviewed Original Research