2024
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett A, Diano S, Huang Y. Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Diabetologia 2024, 67: 724-737. PMID: 38216792, PMCID: PMC10904493, DOI: 10.1007/s00125-023-06073-5.Peer-Reviewed Original ResearchConceptsTen-eleven translocationMuscle insulin sensitivityRNA-seqPGC-1aRegulation of muscle insulin sensitivityType 2 diabetesAnalysis of RNA-seqResponse to environmental cuesGenome-wide expression profilingWild-typeHFD-fedHFD-induced insulin resistanceHigh-fat diet (HFD)-inducedExpression levelsMaintenance of glucoseSkeletal muscle insulin sensitivityAccession numbersSkeletal muscleEnhanced glucose toleranceFamily dioxygenasesMitochondrial respirationSkeletal muscle of humansEnvironmental cuesMitochondrial functionBiological processes
2001
Nucleocytoplasmic mRNA Transport
Huang Y, Carmichael G. Nucleocytoplasmic mRNA Transport. Results And Problems In Cell Differentiation 2001, 34: 139-155. PMID: 11288673, DOI: 10.1007/978-3-540-40025-7_9.Peer-Reviewed Original ResearchConceptsMRNA exportMRNA transportMature mRNA moleculesMRNA nuclear exportViral model systemNuclear pore complexRNA polymerase IIMessenger RNA precursorsFundamental biological processesNucleocytoplasmic mRNA transportRemoval of intronsPolymerase IIPore complexNuclear exportRNA precursorsMRNA moleculesBiological processesProcessing reactionsModel systemCytoplasmDetailed mechanismIntronsPolyadenylationSplicingExport