Featured Publications
Heterogeneity of midgut cells and their differential responses to blood meal ingestion by the mosquito, Aedes aegypti
Cui Y, Franz AWE. Heterogeneity of midgut cells and their differential responses to blood meal ingestion by the mosquito, Aedes aegypti. Insect Biochemistry And Molecular Biology 2020, 127: 103496. PMID: 33188922, PMCID: PMC7739889, DOI: 10.1016/j.ibmb.2020.103496.Peer-Reviewed Original ResearchConceptsIntestinal stem cellsBlood meal ingestionMosquito midgutSingle-nucleus RNA sequencingCell type clustersCell typesVisceral muscle cellsNutrient absorptionCell type compositionHuman pathogenic parasitesNumerous mosquito speciesEC-like cellsBlood meal digestionEnteroendocrine cellsAedes aegyptiBlood-feeding behaviorMeal ingestionCellular homeostasisCellular diversityGenetic compatibilityHematophagous insectsFemale midgutTranscriptional profilesBlood digestionRNA sequencing
2024
A cell atlas of the adult female Aedes aegypti midgut revealed by single-cell RNA sequencing
Wang S, Huang Y, Wang F, Han Q, Ren N, Wang X, Cui Y, Yuan Z, Xia H. A cell atlas of the adult female Aedes aegypti midgut revealed by single-cell RNA sequencing. Scientific Data 2024, 11: 587. PMID: 38839790, PMCID: PMC11153528, DOI: 10.1038/s41597-024-03432-8.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingFat body cellsRNA sequencingSingle-cell levelHemocyte cellsEnteroendocrine cellsVisceral musclesSingle-nucleus resolutionTranscriptome of AeMosquito midgutAedes aegypti midgutMidgut transcriptomeBlood meal digestionCell atlasCardia cellsArbovirus infectionMeal digestionNutrient absorptionMidgut cellsMidgutBody cellsCell clustersPrimary vectorSequenceCells