2020
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis
Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T, Iwakiri Y. Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis. Cellular And Molecular Gastroenterology And Hepatology 2020, 11: 1139-1161. PMID: 33340713, PMCID: PMC7903131, DOI: 10.1016/j.jcmgh.2020.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapillariesCarbon TetrachlorideEndothelial CellsGene Expression RegulationLiver CirrhosisMiceSingle-Cell AnalysisTranscriptomeConceptsLiver sinusoidal endothelial cellsCirrhotic miceSinusoidal endothelial cellsLiver cirrhosisEndothelial cellsIntrahepatic vascular resistanceCarbon tetrachloride inhalationNovel therapeutic strategiesNitric oxide productionCirrhotic mouse liverEC populationsVascular resistanceClinical complicationsLiver fibrosisTherapeutic strategiesCirrhosisOxide productionEndocytic receptorMiceAbstractTextZone 3Extracellular matrix genesVascular ECsLymphatic ECsMouse liver
2018
Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II
Li Y, Yang Y, Zhao Y, Zhang J, Liu B, Jiao S, Zhang X. Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II. Free Radical Biology And Medicine 2018, 131: 251-263. PMID: 30502455, DOI: 10.1016/j.freeradbiomed.2018.11.033.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Inducing FactorAstragalus propinquusFemaleGene Expression RegulationGlutamic AcidHexokinaseHumansHypoxia-Ischemia, BrainInfarction, Middle Cerebral ArteryMembrane Potential, MitochondrialMiceMice, Inbred C57BLMitochondriaMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreNeuronsNeuroprotective AgentsOxygen ConsumptionParthanatosPrimary Cell CultureProtein BindingProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySaponinsTriterpenesConceptsMitochondrial hexokinase-IIApoptosis inducing factorHexokinase-IIRelease of pro-apoptotic proteinsNuclear translocation of apoptosis inducing factorTranslocation of apoptosis inducing factorCollapse of mitochondrial membrane potentialMitochondrial dysfunctionFunctional integrity of mitochondriaMitochondrial permeability transition porePro-apoptotic proteinsBinding to mitochondriaDNA damageIntegrity of mitochondriaMitochondrial membrane potentialPermeability transition poreImpaired mitochondrial functionSimultaneously induced apoptosisNeuronal cell deathTransition porePAR formationMitochondrial functionParthanatosCell deathMitochondria