2011
High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells
Lee MY, Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y. High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells. Biochemical And Biophysical Research Communications 2011, 416: 51-57. PMID: 22079290, PMCID: PMC3237870, DOI: 10.1016/j.bbrc.2011.10.140.Peer-Reviewed Original ResearchConceptsMurine embryonic stem cellsEmbryonic stem cellsBone morphogenetic proteinEB culturesCardiac differentiationCardiomyocyte productionEmbryoid body culturesStem cellsCardiac-specific genesEarly cardiac developmentCardiogenic growth factorsNK2 transcription factorCardiac regenerative medicineMESC linesTranscription factorsCardiac developmentMorphogenetic proteinsEmbryoid bodiesDifferentiation systemDifferentiation periodFunctional cardiomyocytesHigh-density culturesMyosin light chain 2vRegenerative medicineCell-based therapies
2004
Myeloproliferative Disease in Mice with Reduced Presenilin Gene Dosage: Effect of γ-Secretase Blockage †
Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Myeloproliferative Disease in Mice with Reduced Presenilin Gene Dosage: Effect of γ-Secretase Blockage †. Biochemistry 2004, 43: 5352-5359. PMID: 15122901, DOI: 10.1021/bi049826u.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesCell LineageColony-Forming Units AssayEndopeptidasesFemaleGene DosageGranulocytesHematopoiesisLeukocyte CountMacrophagesMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMyeloproliferative DisordersPresenilin-1Presenilin-2Protease InhibitorsConceptsGamma-secretase activityDisease interventionWild-type splenocytesAlzheimer's disease interventionsAmyloid precursor proteinGranulocyte-macrophage colony-forming unitsGamma-secretase inhibitorsGamma-secretase cleavageGranulocyte infiltrationPotential therapyMyeloproliferative diseaseB lymphocytesBone marrowPS inactivationHematopoietic stem cellsColony-forming unitsGranulocytic cells