2019
Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation
Ng R, Manring H, Papoutsidakis N, Albertelli T, Tsai N, See CJ, Li X, Park J, Stevens TL, Bobbili PJ, Riaz M, Ren Y, Stoddard CE, Janssen PM, Bunch TJ, Hall SP, Lo YC, Jacoby DL, Qyang Y, Wright N, Ackermann MA, Campbell SG. Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation. JCI Insight 2019, 5 PMID: 31194698, PMCID: PMC6675562, DOI: 10.1172/jci.insight.128643.Peer-Reviewed Original Research
2002
The p21‐activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe
Qyang Y, Yang P, Du H, Lai H, Kim H, Marcus S. The p21‐activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe. Molecular Microbiology 2002, 44: 325-334. PMID: 11972773, DOI: 10.1046/j.1365-2958.2002.02882.x.Peer-Reviewed Original ResearchConceptsFission yeastP21-activated kinaseMicrotubule dynamicsMicrotubule spindleProper regulationCell endsFission yeast cellsMicrotubule-destabilizing drug thiabendazoleGreen fluorescent proteinShk1 functionCell polarityKinase functionMutant cellsSpindle defectsShk1Microtubule defectsCold sensitiveDrug thiabendazoleKinase activityInterphase microtubulesFusion proteinYeast cellsPotential regulatorFluorescent proteinRelease of cells