2022
Evolution of higher mesenchymal CD44 expression in the human lineage
Ma X, Dighe A, Maziarz J, Neumann E, Erkenbrack E, Hei YY, Liu Y, Suhail Y, Kshitiz, Pak I, Levchenko A, Wagner GP. Evolution of higher mesenchymal CD44 expression in the human lineage. Evolution Medicine And Public Health 2022, 10: 447-462. PMID: 36148042, PMCID: PMC9487634, DOI: 10.1093/emph/eoac036.Peer-Reviewed Original ResearchCell type-specific factorsType-specific factorsEndometrial stromal fibroblastsHuman lineageCell type-specific functionsCell typesExtracellular matrix receptorsExpression increasesGene expression increasesReporter gene experimentsEvolutionary changePositive selectionFunction of CD44Regulatory elementsMatrix receptorsRegulatory mechanismsGene experimentsCancer progressionInvasibilityCD44 expressionFetal-maternal interactionIsoform expressionLineagesExpressionStromal fibroblasts
2020
Isoform‐resolved correlation analysis between mRNA abundance regulation and protein level degradation
Salovska B, Zhu H, Gandhi T, Frank M, Li W, Rosenberger G, Wu C, Germain P, Zhou H, Hodny Z, Reiter L, Liu Y. Isoform‐resolved correlation analysis between mRNA abundance regulation and protein level degradation. Molecular Systems Biology 2020, 16: msb199170. PMID: 32175694, PMCID: PMC7073818, DOI: 10.15252/msb.20199170.Peer-Reviewed Original ResearchConceptsProtein degradationGenome-wide correlation analysisGene dosage variationProtein abundance levelsStable isotope-labeled amino acidsIndividual protein isoformsSpecific biological processesAlternative splicing isoformsData-independent acquisition mass spectrometryIsotope-labeled amino acidsAcquisition mass spectrometryProtein degradation ratesIntron retentionCellular functionsProtein isoformsSplicing isoformsCellular organellesTranscriptome variabilitySame geneTurnover controlRegulatory mechanismsBiological processesSpecific mRNAsTight associationAbundance levels