2023
How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches
Mineur Y, Picciotto M. How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches. Journal Of Neurochemistry 2023, 167: 3-15. PMID: 37621094, PMCID: PMC10616967, DOI: 10.1111/jnc.15943.Peer-Reviewed Original Research
2020
Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning
Mineur YS, Ernstsen C, Islam A, Maibom KL, Picciotto MR. Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning. Genes Brain & Behavior 2020, 19: e12677. PMID: 32447811, PMCID: PMC8018799, DOI: 10.1111/gbb.12677.Peer-Reviewed Original ResearchConceptsFear learningShort-term learningNumber of paradigmsCued fearLight/dark boxFear conditioningContextual memoryStress-related behaviorsStress-induced reactivityTerm learningBrain circuitsRobust effectM1 mAChRHippocampal acetylcholineM1 muscarinic ACh receptorsNovelty-suppressed feeding testLearningMemoryDark boxHippocampus of malesM1 muscarinic acetylcholine receptorHippocampal knockdownFearMuscarinic ACh receptorsGroups of mice
2019
The role of acetylcholine in negative encoding bias: Too much of a good thing?
Mineur YS, Picciotto MR. The role of acetylcholine in negative encoding bias: Too much of a good thing? European Journal Of Neuroscience 2019, 53: 114-125. PMID: 31821620, PMCID: PMC7282966, DOI: 10.1111/ejn.14641.Peer-Reviewed Original ResearchConceptsPotential neural pathwaysSymptoms of anxietyAffective processesSustained attentionStressful eventsCore symptomsFacilitate learningAppropriate learningNeural pathwaysRole of acetylcholineGood thingLevels of AChLearningDepressionBiasDepressive episodeNeuromodulatory roleCholinergic signalingAnimal studiesAnxietyMemoryAcetylcholine SignalingHigh levelsEncodingACh