Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus
Calarco CA, Li Z, Taylor SR, Lee S, Zhou W, Friedman JM, Mineur YS, Gotti C, Picciotto MR. Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus. European Journal Of Neuroscience 2018, 48: 1600-1619. PMID: 29791746, PMCID: PMC6251769, DOI: 10.1111/ejn.13966.Peer-Reviewed Original ResearchPOMC cellsArcuate nucleusFood intakeOrexigenic agouti-related peptideNicotinic acetylcholine receptor subtypesAnorexigenic pro-opiomelanocortin (POMC) neuronsDecrease food intakePro-opiomelanocortin (POMC) neuronsAcetylcholine receptor subtypesMRNA levelsAgouti-related peptideNicotinic agonist cytisineNicotinic acetylcholine receptorsSubunit mRNA levelsNeuronal cell typesAnorexigenic neuronsNicotinic regulationNicotinic modulationSmall hairpin RNAHypothalamic regionsReal-time PCRReceptor subtypesAgonist cytisineΑ7 subunitAcetylcholine receptorsInteraction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice
Mineur YS, Cahuzac EL, Mose TN, Bentham MP, Plantenga ME, Thompson DC, Picciotto MR. Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice. Neuropsychopharmacology 2018, 43: 2118-2125. PMID: 29472646, PMCID: PMC6098039, DOI: 10.1038/s41386-018-0024-x.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAdrenergic alpha-AgonistsAlkaloidsAmygdalaAnimalsAnxietyAzocinesCholinesterase InhibitorsDepressionFemaleGene Knockdown TechniquesGuanfacineMaleMiceMice, Inbred C57BLNicotinic AgonistsNorepinephrineParasympathetic Nervous SystemQuinolizinesReceptors, Adrenergic, alpha-2Signal TransductionSympathetic Nervous SystemConceptsAntidepressant-like effectsNoradrenergic systemMale C57BL/6J miceDepression-related behaviorsDepression-like phenotypeNicotinic acetylcholine receptorsAntidepressant efficacyCholinergic interactionsNE terminalsC57BL/6J miceShRNA-mediated knockdownAgonist guanfacineAgonist cytisineClinical studiesSmoking relapseΑ2A receptorsAcute abstinenceBrain areasAcetylcholine receptorsAcetylcholineGuanfacineAmygdalaBehavioral effectsAnxiety disordersStress pathways