Harnessing small extracellular vesicles for pro-oxidant delivery: novel approach for drug-sensitive and resistant cancer therapy
Kang C, Ren X, Lee D, Ramesh R, Nimmo S, Yang-Hartwich Y, Kim D. Harnessing small extracellular vesicles for pro-oxidant delivery: novel approach for drug-sensitive and resistant cancer therapy. Journal Of Controlled Release 2023, 365: 286-300. PMID: 37992875, PMCID: PMC10872719, DOI: 10.1016/j.jconrel.2023.11.031.Peer-Reviewed Original ResearchSmall extracellular vesiclesMDR cancer cellsMultidrug resistanceCancer cellsDrug resistanceReactive oxygen speciesExtracellular vesiclesOvarian cancer cellsDrug-resistant cancersApoptotic cell deathCancer treatment strategiesTreatment strategiesTherapy highlightClinical problemMDR tumorsDrug responsivenessP-glycoproteinPotent anticancer activityCancer treatmentRedox balanceATP productionOxidative stressTumorsVivo studiesMitochondrial dysfunctionNRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y, Tan H, Wang Q, Jiang Z, Yang K, Garcia J, Chambers S, Chapman E, Ooi A, Yang-Hartwich Y, Stockwell B, Zhang D. NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Science Advances 2023, 9: eade9585. PMID: 36724221, PMCID: PMC9891695, DOI: 10.1126/sciadv.ade9585.Peer-Reviewed Original ResearchConceptsLabile iron poolNFE2L2/Human ovarian cancer tissuesCancer cellsOvarian cancer cell linesOvarian cancer tissuesIntracellular labile iron poolIron homeostasisCancer cell linesPreclinical modelsNrf2 inhibitionCancer tissuesNrf2 levelsCancer treatmentFerroptotic deathNrf2Ferroptosis resistanceKnockout cellsCell linesUntapped strategyFerroptosisIron poolCellsHomeostasisExpression