2023
Harnessing small extracellular vesicles for pro-oxidant delivery: novel approach for drug-sensitive and resistant cancer therapy
Kang C, Ren X, Lee D, Ramesh R, Nimmo S, Yang-Hartwich Y, Kim D. Harnessing small extracellular vesicles for pro-oxidant delivery: novel approach for drug-sensitive and resistant cancer therapy. Journal Of Controlled Release 2023, 365: 286-300. PMID: 37992875, PMCID: PMC10872719, DOI: 10.1016/j.jconrel.2023.11.031.Peer-Reviewed Original ResearchSmall extracellular vesiclesMDR cancer cellsMultidrug resistanceCancer cellsDrug resistanceReactive oxygen speciesExtracellular vesiclesOvarian cancer cellsDrug-resistant cancersApoptotic cell deathCancer treatment strategiesTreatment strategiesTherapy highlightClinical problemMDR tumorsDrug responsivenessP-glycoproteinPotent anticancer activityCancer treatmentRedox balanceATP productionOxidative stressTumorsVivo studiesMitochondrial dysfunction
2019
An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors
Zhang W, Sviripa VM, Kril L, Yu T, Xie Y, Hubbard W, Sullivan P, Chen X, Zhan CG, Yang-Hartwich Y, Evers BM, Spear B, Gedaly R, Watt DS, Liu C. An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors. Journal Of Medicinal Chemistry 2019, 62: 11348-11358. PMID: 31774672, PMCID: PMC7560992, DOI: 10.1021/acs.jmedchem.9b01685.Peer-Reviewed Original Research