Microbiota-derived acetate enhances host antiviral response via NLRP3
Niu J, Cui M, Yang X, Li J, Yao Y, Guo Q, Lu A, Qi X, Zhou D, Zhang C, Zhao L, Meng G. Microbiota-derived acetate enhances host antiviral response via NLRP3. Nature Communications 2023, 14: 642. PMID: 36746963, PMCID: PMC9901394, DOI: 10.1038/s41467-023-36323-4.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAnimalsAntiviral AgentsHumansInflammasomesInfluenza A virusMiceMicrobiotaNLR Family, Pyrin Domain-Containing 3 ProteinConceptsViral infectionGut-lung axisRespiratory viral infectionsNLRP3-deficient miceIFN-I productionHost immune responsePathogenic viral infectionPotential therapeutic targetType I interferonHost antiviral responseRespiratory virusesIAV infectionMAVS aggregationNLRP3 inflammasomeDeficient miceImmune responseProtective effectTherapeutic targetI interferonGut microbiotaAntiviral responseNLRP3Host defenseInfectionEnhanced induction