2021
Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites
Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites. MBio 2021, 12: 10.1128/mbio.03601-20. PMID: 33785628, PMCID: PMC8092315, DOI: 10.1128/mbio.03601-20.Peer-Reviewed Original ResearchConceptsKetogenic dietGut microbiotaProportion of fatLipid metabolismGlucose intoleranceInsulin resistanceFat accumulationMouse trialsNeurodegenerative diseasesLipid accumulationMore fat accumulationInduced glucose intoleranceLipid metabolism disordersAffected lipid metabolismMetabolism disordersMetabolic disordersGlucose homeostasisGlucose metabolismSource of fatHuman studiesHigh fatTreatment of diseasesMiceBeneficial effectsWeight loss
2020
Lactobacillus Mucosae Strain Promoted by a High-Fiber Diet in Genetic Obese Child Alleviates Lipid Metabolism and Modifies Gut Microbiota in ApoE-/- Mice on a Western Diet
Jiang T, Wu H, Yang X, Li Y, Zhang Z, Chen F, Zhao L, Zhang C. Lactobacillus Mucosae Strain Promoted by a High-Fiber Diet in Genetic Obese Child Alleviates Lipid Metabolism and Modifies Gut Microbiota in ApoE-/- Mice on a Western Diet. Microorganisms 2020, 8: 1225. PMID: 32806628, PMCID: PMC7464838, DOI: 10.3390/microorganisms8081225.Peer-Reviewed Original ResearchWestern dietHigh-fiber dietGut microbiotaApoE-/- miceModifies gut microbiotaTreatment of hyperlipidemiaSevere lipid accumulationGut microbiota structureProbiotic candidate strainSupplementation of probioticsNext-generation probioticsMetabolic endotoxemiaAortic sinusHuman-derived strainsHyperlipidemiaTherapeutic methodsLipid metabolismAtherosclerosisLipid accumulationMiceSelection of candidatesApoEMicrobiota structureDietProbiotics
2019
Timing of Calorie Restriction in Mice Impacts Host Metabolic Phenotype with Correlative Changes in Gut Microbiota
Zhang L, Xue X, Zhai R, Yang X, Li H, Zhao L, Zhang C. Timing of Calorie Restriction in Mice Impacts Host Metabolic Phenotype with Correlative Changes in Gut Microbiota. MSystems 2019, 4: 10.1128/msystems.00348-19. PMID: 31796564, PMCID: PMC6890928, DOI: 10.1128/msystems.00348-19.Peer-Reviewed Original ResearchGut microbiotaCalorie restrictionMetabolic phenotypeLate-night eatingRestricted calorie intakeSystemic inflammatory markersIntestinal barrier functionCalorie-restricted miceHost metabolic phenotypeEffects of CRRestriction of foodGut microbiota structureExtended fasting periodPhysiological changesInflammatory markersNormal chowFat accumulationFood intakeCalorie intakeCR miceGlucose metabolismMuscle lossOverall healthFasting periodMice