Featured Publications
Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice
Yang X, Wang Z, Niu J, Zhai R, Xue X, Wu G, Fang Y, Meng G, Yuan H, Zhao L, Zhang C. Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice. Microbiome 2023, 11: 62. PMID: 36978130, PMCID: PMC10052834, DOI: 10.1186/s40168-023-01507-z.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetesBeta-cell destructionGut microbiotaGut microbiomeDextran sulfate sodium treatmentAutoimmune type 1 diabetesCell destructionIDD developmentDysbiotic gut microbiotaGerm-free micePotential human relevanceType 1 diabetesNormal gut microbiomeGut pathobiontPancreatic inflammationC57BL/6 miceLocal inflammationNormal dietWildtype miceAnimal modelsDiabetesSodium treatmentPathobiontsPancreasHuman relevance
2018
Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet
Wang R, Li H, Yang X, Xue X, Deng L, Shen J, Zhang M, Zhao L, Zhang C. Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. Frontiers In Microbiology 2018, 9: 1602. PMID: 30079055, PMCID: PMC6062601, DOI: 10.3389/fmicb.2018.01602.Peer-Reviewed Original ResearchHepatic transcriptional profilePreM groupGut microbiotaLiver steatosisNon-alcoholic fatty liver diseaseDietary weight loss programObesity-associated gut microbiotaLipid metabolismPeroxisome proliferator-activated receptor alphaProliferator-activated receptor alphaDysbiotic gut microbiotaLiver macrovesicular steatosisFatty liver diseaseNormal chow dietWeight loss programC57BL/6J male miceNormal hepatic physiologyObese human donorsLiver diseaseChow dietLoss programMice fedHuman gut microbiotaMacrovesicular steatosisMetabolic deterioration