2013
Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy
Lin Q, Huang Y, Booth CJ, Haase VH, Johnson RS, Simon M, Giordano FJ, Yun Z. Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy. Journal Of The American Heart Association 2013, 2: e000548. PMID: 24326162, PMCID: PMC3886757, DOI: 10.1161/jaha.113.000548.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAnimalsBasic Helix-Loop-Helix Transcription FactorsCardiomegalyCytokinesDisease Models, AnimalGene Expression RegulationGenetic Predisposition to DiseaseHypoxia-Inducible Factor 1, alpha SubunitInflammation MediatorsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyocytes, CardiacPhenotypeSignal TransductionTime FactorsVon Hippel-Lindau Tumor Suppressor ProteinConceptsPathological cardiac hypertrophyCardiac hypertrophyHypoxia-inducible factor-2Hypoxia-signaling pathwayHypoxia-inducible factor (HIF) pathwayVon Hippel-Lindau (VHL) geneTranscription factorsUncharacterized mechanismAdipose tissueAdipocytes resultsHIF activationObesity-associated cardiomyopathyChemotactic protein-1Protein 1Activated T cellsDirect roleEssential roleCardiomyopathy-associated genesFactor 2Genetic deletionFactor pathwayUndefined mechanismDeletionNuclear factorGenes
2012
A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart
Zhang HS, Liu D, Huang Y, Schmidt S, Hickey R, Guschin D, Su H, Jovin IS, Kunis M, Hinkley S, Liang Y, Hinh L, Spratt SK, Case CC, Rebar EJ, Ehrlich BE, Ehrlich B, Gregory P, Giordano F. A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart. Molecular Therapy 2012, 20: 1508-1515. PMID: 22828502, PMCID: PMC3412484, DOI: 10.1038/mt.2012.80.Peer-Reviewed Original ResearchConceptsHeart failureZinc finger protein transcription factorsSingle gene regulationZinc finger transcriptional repressorDiverse DNA sequencesProtein transcription factorsDisease-related genesDisease-related proteinsGene repressionZFP TFsTranscriptional repressorTranscription factorsDNA sequencesPotent repressionPLN expressionHuman diseasesRepressorContractile functionDrug targetsFailing HeartTherapeutic inhibitionAnimal modelsReuptake kineticsRepressionTherapeutic interventions
2008
Chromogranin B Regulates Calcium Signaling, Nuclear Factor &kgr;B Activity, and Brain Natriuretic Peptide Production in Cardiomyocytes
Heidrich FM, Zhang K, Estrada M, Huang Y, Giordano FJ, Ehrlich BE. Chromogranin B Regulates Calcium Signaling, Nuclear Factor &kgr;B Activity, and Brain Natriuretic Peptide Production in Cardiomyocytes. Circulation Research 2008, 102: 1230-1238. PMID: 18420944, PMCID: PMC2952358, DOI: 10.1161/circresaha.107.166033.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAngiotensin IIAnimalsCalciumCalcium SignalingCardiomegalyCells, CulturedChromogranin BInositol 1,4,5-Trisphosphate ReceptorsMyocytes, CardiacNatriuretic Peptide, BrainNF-kappa BNFATC Transcription FactorsPromoter Regions, GeneticRatsTranscription, GeneticVasoconstrictor AgentsConceptsBrain natriuretic peptideAngiotensin IICardiac hypertrophyBNP productionChromogranin BNuclear factorNuclear factor-kappaB activityNatriuretic peptide productionActivated T cellsNuclear factor-kappaBLuciferase reporter assaysHeart failureNatriuretic peptideBasal secretionCardiovascular diseaseT cellsKappaB activityFactor-kappaBHypertrophyCGB expressionBNP promoterPotent inducerAdult cardiomyocytesOctapeptide hormoneCalcium signaling
2006
p204 Protein Overcomes the Inhibition of the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes by Id Proteins*
Ding B, Liu CJ, Huang Y, Yu J, Kong W, Lengyel P. p204 Protein Overcomes the Inhibition of the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes by Id Proteins*. Journal Of Biological Chemistry 2006, 281: 14893-14906. PMID: 16556596, DOI: 10.1074/jbc.m511748200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell Line, TumorFeedback, PhysiologicalGATA4 Transcription FactorGene Expression RegulationHomeobox Protein Nkx-2.5Homeodomain ProteinsInhibitor of Differentiation Protein 1Inhibitor of Differentiation Protein 2Inhibitor of Differentiation ProteinsMiceMyocytes, CardiacNuclear ProteinsPhosphoproteinsTranscription FactorsTranscriptional ActivationConceptsD proteinsP204 proteinP19 cellsP19 murine embryonal carcinoma cellsEmbryonal carcinoma stem cellsNuclear export signalMurine embryonal carcinoma cellsP19 embryonal carcinoma stem cellsCardiac transcription factor GATA4Embryonal carcinoma cellsTranscription factor GATA4Carcinoma stem cellsExport signalSynergistic transactivationTranscription factorsNKX2.5 proteinPositive feedback loopCardiac myocytesDifferentiation proteinGATA4ProteinStem cellsDifferentiationP204Carcinoma cellsp204 Is Required for the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes ITS EXPRESSION IS ACTIVATED BY THE CARDIAC GATA4, NKX2.5, AND TBX5 PROTEINS*
Ding B, Liu CJ, Huang Y, Hickey RP, Yu J, Kong W, Lengyel P. p204 Is Required for the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes ITS EXPRESSION IS ACTIVATED BY THE CARDIAC GATA4, NKX2.5, AND TBX5 PROTEINS*. Journal Of Biological Chemistry 2006, 281: 14882-14892. PMID: 16556595, DOI: 10.1074/jbc.m511747200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCell Line, TumorChromatinGATA4 Transcription FactorGene Expression Regulation, DevelopmentalHomeobox Protein Nkx-2.5Homeodomain ProteinsMiceMolecular Sequence DataMuscle, SkeletalMyocytes, CardiacNuclear ProteinsPhosphoproteinsT-Box Domain ProteinsTranscription FactorsConceptsNuclear export signalExport signalTranscription factorsP19 cellsC2C12 skeletal muscle myoblastsP19 murine embryonal carcinoma cellsEmbryonal carcinoma stem cellsAdult mouse tissuesMurine embryonal carcinoma cellsTBX5 transcription factorSkeletal muscle myoblastsEmbryonal carcinoma cellsCarcinoma stem cellsP204 expressionP204 proteinExpression of GATA4Regulatory regionsTBX5 proteinReporter constructsAntisense RNAMuscle myoblastsCardiac myocytesMouse tissuesStem cellsGATA4