2005
Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation
Fernández-Hernando C, Suárez Y, Lasunción MA. Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation. Molecular And Cellular Neuroscience 2005, 29: 591-602. PMID: 15951198, DOI: 10.1016/j.mcn.2005.04.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCholesterolDiterpenesEnzyme ActivationEnzyme InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsIntracellular Signaling Peptides and ProteinsLovastatinNeuritesPC12 CellsPhosphorylationProtein PrenylationProtein Serine-Threonine KinasesRatsRho-Associated KinasesRhoA GTP-Binding ProteinSterolsTerpenesConceptsNeurite outgrowthNon-sterol mevalonate derivativesPC-12 cell differentiationCellular lipid compositionNon-sterol isoprenoidsEffects of geranylgeraniolBiosynthetic pathwayProtein prenylationRole of cholesterolCofilin phosphorylationRhoA signalingMevalonate derivativesA ReductaseRhoA activationCell differentiationCoenzyme A (HMG-CoA) reductaseLovastatin inhibitsPC-12 cellsCholesterol biosynthesisPathway inactivationRhoA kinaseLipid compositionOutgrowthGeranylgeraniolInhibition
2004
Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin
Suárez Y, Fernández C, Gómez-Coronado D, Ferruelo AJ, Dávalos A, Martínez-Botas J, Lasunción MA. Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. Cardiovascular Research 2004, 64: 346-355. PMID: 15485695, DOI: 10.1016/j.cardiores.2004.06.024.Peer-Reviewed Original ResearchConceptsLDL receptor activityLow-density lipoproteinReceptor activityLow density lipoprotein receptor activityPlasma LDL cholesterol levelsLDL cholesterol levelsLipoprotein receptor activityEstrogen receptor modulatorsBreast cancer therapyReceptor mRNA levelsLDL receptor mRNA levelsLDL receptor expressionCholesterol-lowering activityDose-dependent mannerHigh LDL concentrationsHypolipidemic effectsMOLT-4 cellsCholesterol levelsReceptor expressionReceptor modulatorsEstrogen receptorTamoxifenLDL concentrationLDL uptakeLDL receptor
2001
Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives
Martı́nez-Botas J, Ferruelo A, Suárez Y, Fernández C, Gómez-Coronado D, Lasunción M. Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. Biochimica Et Biophysica Acta 2001, 1532: 185-194. PMID: 11470239, DOI: 10.1016/s1388-1981(01)00125-1.Peer-Reviewed Original ResearchConceptsCell proliferationLow-density lipoprotein cholesterolCell cycle progressionDose-dependent effectCell cycle distributionCell cycleCycle progressionLipoprotein cholesterolConcentrations of lovastatinCholesterol supplyCycle distributionCholesterolLovastatinHuman cell linesCell linesCholesterol biosynthesisCholesterol-free mediumNormal cell cyclingM phaseProgressionProliferationPresent studyHL-60Mevalonate derivativesCell cycling