2015
VEGF-Induced Expression of miR-17–92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis
Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, del Rey M, van Solingen C, Yu J, Fernández-Hernando C, Sessa WC, Suárez Y. VEGF-Induced Expression of miR-17–92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circulation Research 2015, 118: 38-47. PMID: 26472816, PMCID: PMC4703066, DOI: 10.1161/circresaha.115.307408.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationEndothelium, VascularGene Expression RegulationHuman Umbilical Vein Endothelial CellsHumansMAP Kinase Signaling SystemMiceMice, KnockoutMicroRNAsNeovascularization, PhysiologicVascular Endothelial Growth Factor AConceptsMiR-17Elk1 activationEndothelial angiogenic functionEC proliferationRegulation of angiogenesisTranscription activationTranscriptional programsGenetic evidenceCluster expressionTumor angiogenesisAngiogenic sproutingVEGF stimulationRescue experimentsRetinal angiogenesisRegulate angiogenesisLines of evidenceEndothelial cell functionAngiogenic switchPhysiological retinal angiogenesisAngiogenic functionDevelopmental retinal angiogenesisCell functionTumor developmentRegulationCrucial mediator
2014
Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells
Chamorro-Jorganes A, Araldi E, Rotllan N, Cirera-Salinas D, Suárez Y. Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. Journal Of Cell Science 2014, 127: 1169-1178. PMID: 24463821, PMCID: PMC3953812, DOI: 10.1242/jcs.130518.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Lewis LungCells, CulturedFibroblast Growth Factor 2Gene ExpressionGlypicansHuman Umbilical Vein Endothelial CellsHumansMaleMiceMicroRNAsNeoplasm TransplantationNeovascularization, PathologicNeovascularization, PhysiologicReceptor, Fibroblast Growth Factor, Type 1RNA InterferenceSignal Transduction
2012
miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish
Stahlhut C, Suárez Y, Lu J, Mishima Y, Giraldez AJ. miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish. Development 2012, 139: 4356-4365. PMID: 23132244, PMCID: PMC3509730, DOI: 10.1242/dev.083774.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell DifferentiationCell LineEndothelial CellsHuman Umbilical Vein Endothelial CellsHumansMicroRNAsNeovascularization, PhysiologicSignal TransductionVascular Endothelial Growth Factor AZebrafishConceptsMiR-1/206Post-transcriptional modulatorsMiRNA-target interactionsMiR-1Appropriate physiological responsesRegulation of VEGFAZebrafish developmentEmbryonic developmentTarget protectorNovel functionPrecise regulationGene expressionMorphogenetic activityDevelopmental angiogenesisPutative targetsRegulate angiogenesisEssential processMiR-206Physiological responsesCellular communicationVEGFA expressionGrowth factorVascular endothelial growth factorExpressionAngiogenesis