2018
MicroRNAs in endothelial cell homeostasis and vascular disease
Fernández-Hernando C, Suárez Y. MicroRNAs in endothelial cell homeostasis and vascular disease. Current Opinion In Hematology 2018, 25: 227-236. PMID: 29547400, PMCID: PMC6175704, DOI: 10.1097/moh.0000000000000424.Peer-Reviewed Original ResearchConceptsVascular diseaseVascular disease preventionPotential therapeutic targetEndothelial cell homeostasisEndothelial cell functionEndothelial dysfunctionEndothelial functionVascular dysfunctionTherapeutic applicationsPotential therapeutic applicationsInvolvement of miRNAsDysregulation of miRNAsEndothelial homeostasisTherapeutic targetDisease preventionDiseaseCell functionRegulatory circuitsCritical modulatorUnanticipated roleTarget genesCell homeostasisDysfunctionMiRNAsHomeostasis
2015
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.
Araldi E, Chamorro-Jorganes A, van Solingen C, Fernandez-Hernando C, Suarez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Current Vascular Pharmacology 2015, 13: 291-304. PMID: 26156264, DOI: 10.2174/15701611113119990012.Peer-Reviewed Original ResearchConceptsPost-transcriptional levelMonocyte-derived phagocytesFoam cell formationGene regulatorsCell adhesion moleculeModulating microRNAsVascular smooth muscle cellsCell differentiationArterial tree resultsVascular diseaseCell formationMicroRNAsSmooth muscle cellsCap formationVascular cellsFibrous cap formationPotential therapeutic applicationsUnstable fibrous capUnstable coronary syndromesAtherosclerotic vascular diseaseTree resultsMuscle cellsChronic inflammatory diseaseProgression of atherosclerosisLesion-prone sites