2017
Macrophage deficiency of miR‐21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis
Canfrán‐Duque A, Rotllan N, Zhang X, Fernández‐Fuertes M, Ramírez‐Hidalgo C, Araldi E, Daimiel L, Busto R, Fernández‐Hernando C, Suárez Y. Macrophage deficiency of miR‐21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Molecular Medicine 2017, 9: 1244-1262. PMID: 28674080, PMCID: PMC5582411, DOI: 10.15252/emmm.201607492.Peer-Reviewed Original ResearchConceptsER stress-induced apoptosisPost-translational degradationFoam cell formationMiR-21MiR-21 target genesTarget genesJNK signalingPlaque necrosisAbundant miRNAVascular inflammationAccumulation of lipidsHematopoietic cellsMacrophage apoptosisCell formationAberrant expressionMacrophage deficiencyApoptosisCholesterol effluxProgression of atherosclerosisChronic inflammatory diseasePathophysiological processesInflammatory cellsExpressionInflammatory diseasesCardiovascular disease
2007
Proteomic Analysis of the Resistance to Aplidin in Human Cancer Cells
González-Santiago L, Alfonso P, Suárez Y, Núñez A, García-Fernández LF, Alvarez E, Muñoz A, Casal JI. Proteomic Analysis of the Resistance to Aplidin in Human Cancer Cells. Journal Of Proteome Research 2007, 6: 1286-1294. PMID: 17338558, DOI: 10.1021/pr060430+.Peer-Reviewed Original ResearchConceptsProtein disulfide isomeraseRole of PDINumber of proteinsRab geranylgeranyltransferaseInduction of apoptosisHuman cancer cellsDisulfide isomeraseProteomic approachMembrane proteinsProteomic analysisMALDI-TOF mass spectrometryApoptosis pathwayDatabase interrogationHeLa cellsCyclophilin AProteinCancer cellsAplidinApoptosisCystathionine gamma lyaseCellsMass spectrometryGeranylgeranyltransferaseEzrinIsomerase